Cytochemiai, immunológiai és génátrendezödés vizsgálatok felnöttkori akut leukaemiákban.

Translated title of the contribution: Cytochemical, immunologic and gene rearrangement studies in adult acute leukemia

K. Pálóczi, K. Natonek, A. Mód, A. Poros, R. Mihalik, J. Földi, M. Benczur, Z. Hollán

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Results of morphological, cytochemical and immunological studies performed in adult acute leukaemias have been compared. Thirty one cases proved to be acute myeloid leukaemia, while 25 cases were shown to be acute lymphoid leukaemia. Based on our results we conclude that immunophenotyping with monoclonal antibodies does not help in distinguishing the subtypes of AML. For purposes of clinical diagnosis cytochemical methods are valuable. On the other hand the monoclonal antibodies are essential in distinguishing the very immature myeloid and lymphoid leukaemias and this is of great importance from the clinical point of view, in determining therapy. Moreover, the diagnosis of acute lymphoid leukaemias is not possible without the specific monoclonal antibodies. Their application is first of all in haematological centers caring for leukaemia patients nowadays already obligatory. Gene rearrangement studies make the diagnosis more accurate and help in the diagnosis of leukaemias of unknown immunological origin.

Translated title of the contributionCytochemical, immunologic and gene rearrangement studies in adult acute leukemia
Original languageHungarian
Pages (from-to)1119-1124
Number of pages6
JournalOrvosi hetilap
Volume131
Issue number21
Publication statusPublished - May 27 1990

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Pálóczi, K., Natonek, K., Mód, A., Poros, A., Mihalik, R., Földi, J., Benczur, M., & Hollán, Z. (1990). Cytochemiai, immunológiai és génátrendezödés vizsgálatok felnöttkori akut leukaemiákban. Orvosi hetilap, 131(21), 1119-1124.