Cystitis is associated with TRPVIb-downregulation in rat dorsal root ganglia

Ana Charrua, Carlos Reguenga, Cleoper C. Paule, Istvan Nagy, Francisco Cruz, António Avelino

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The recently identified splice variant of the transient receptor vanilloid type I (TRPVI) molecule, TRPVIb, produces a negative-dominant effect on the responsiveness of theTRPVI channel, which is increased by peripheral inflammatory processes. Here, we studied, using real-time polymerase chain reaction, whether cyclophosphamide injection-evoked cystitis is associated with altered TRPVI/TRPVIb expression in the L5-L6 dorsal root ganglia, which innervate the urinary bladder. We found that while TRPVI mRNA expression was unchanged, the amount of TRPVIb transcript was significantly reduced in L5-L6 dorsal root ganglia during cystitis. These data indicate that peripheral inflammatory events induce changes inTRPVIb expression in primary sensory neurons, which may result in increased responsiveness of the TRPVI channel.

Original languageEnglish
Pages (from-to)1469-1472
Number of pages4
JournalNeuroreport
Volume19
Issue number15
DOIs
Publication statusPublished - Oct 8 2008

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Keywords

  • Inflammation
  • Pain
  • TRPVI
  • Urinary bladder
  • Vanilloid receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Charrua, A., Reguenga, C., Paule, C. C., Nagy, I., Cruz, F., & Avelino, A. (2008). Cystitis is associated with TRPVIb-downregulation in rat dorsal root ganglia. Neuroreport, 19(15), 1469-1472. https://doi.org/10.1097/WNR.0b013e32830f1e73