Cystic fibrosis-style changes in the early phase of pancreatitis

Anita Balázs, P. Hegyi

Research output: Contribution to journalArticle

Abstract

The early phase of both acute and chronic pancreatitis can be characterized by disrupt level and function of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, decreased bicarbonate secretion, intraductal acidosis, decrease of fluid secretion and elevation of mucoprotein levels. It is almost needless to say that these intrapancreatic changes are very similar to the pathophysiological changes observed in cystic fibrosis. The aim of this mini review is to describe the development of the above mentioned pathological observations in details, moreover highlight some future therapeutic opportunities in pancreatitis.

Original languageEnglish
Pages (from-to)S12-S17
JournalClinics and Research in Hepatology and Gastroenterology
Volume39
DOIs
Publication statusPublished - Sep 1 2015

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Mucoproteins
Fluids and Secretions
Cystic Fibrosis Transmembrane Conductance Regulator
Chronic Pancreatitis
Bicarbonates
Acidosis
Cystic Fibrosis
Pancreatitis
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cystic fibrosis-style changes in the early phase of pancreatitis. / Balázs, Anita; Hegyi, P.

In: Clinics and Research in Hepatology and Gastroenterology, Vol. 39, 01.09.2015, p. S12-S17.

Research output: Contribution to journalArticle

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