Cystatin C is a suitable marker of glomerular function in children with cancer

Edit Bárdi, Ildikó Bobok, Anna V. Oláh, Éva Oláh, János Kappelmayer, Csongor Kiss

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Antineoplastic chemotherapy is associated with nephrotoxic side effects. Data on nephrotoxicity in childhood cancer are scanty, in part because of the difficulties in obtaining reliable markers of glomerular function. We used serum cystatin C (cysC) to assess glomerular function. CysC was compared with serum creatinine concentration (SCr), the endogenous creatinine clearence (CCr), and the calculated Counahan formula (CCounahan) in children with leukemia and solid tumors. CysC was measured by particle-enhanced immunoturbidimetric assay. Serum and urinary creatinine concentrations were determined by the Jaffé method. Samples were obtained from 258 children, including 92 receiving anticancer chemotherapy, 108 long-term survivors, 40 children without any renal disease, and 18 patients with chronic renal insufficiency. CysC of patients on current chemotherapy was assessed both before and after treatment. Significant correlations were found between cysC and SCr and between 1/cysC and CCounahan. CysC increased significantly after cisplatin, methotrexate, cyclophosphamide, ifosfamide, and multimodality treatment. Our results suggest that cysC measurement can be used to characterize glomerular function in children with cancer.

Original languageEnglish
Pages (from-to)1145-1147
Number of pages3
JournalPediatric Nephrology
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 1 2004

Keywords

  • Childhood cancer
  • Cystatin C
  • Glomerular function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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