CYP46 T/C polymorphism is not associated with Alzheimer's dementia in a population from Hungary

Anna Juhász, Ágnes Rimanóczy, Krisztina Boda, Gábor Vincze, Gyozo Szlávik, Marianna Zana, Annamária Bjelik, Magdolna Pákáski, Nikoletta Bódi, András Palotás, Zoltán Janka, János Kálmán

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Multiple genetic and environmental factors regulate the susceptibility to Alzheimer's disease (AD). Recently, several independent studies have reported that a locus on chromosome 14q32.1, where a gene encoding a cholesterol degrading enzyme of the brain, called 24-hydroxylase (CYP46A1) is located, has been linked with AD. The single nucleotide polymorphism (T/C) in intron 2 of CYP46 gene has been found to confer the risk for AD. The water soluble 24(S)-hydroxysterol is the product of the CYP46A1, and elevated plasma and cerebrospinal fluid hydroxysterol concentrations have been found in AD, reflecting increased brain cholesterol turnover or cellular degradation, due to the neurodegenerative process. A case-control study was performed on 125 AD and 102 age- and gender-matched control subjects (CNT) from Hungary, to test the association of CYP46 T/C and apolipoprotein E (ApoE) gene polymorphisms in AD. The frequency of the CYP46 C allele was similar (χ2=0.647, df=1, P=0.421, exact P=0.466, OR=0.845; 95% CI: 0.561-1.274) in both groups (CNT: 27%; 95% CI: 21.3-33.4; AD 30%; 95% CI: 25.0-36.3). The ApoE ε4 allele was significantly over-represented (χ2=11.029, df=2, P=0.004) in the AD population (23.2%; 95% CI: 18.2-29.0) when compared with the CNT (11.3%; 95% CI: 7.4-16.6). The presence or absence of one or two CYP46C alleles together with the ApoE ε4 allele did not increase the risk of AD (OR=3.492; 95% CI: 1.401-8.707; P<0.007 and OR=3.714; 95% CI: 1.549-8.908; P<0.003, respectively). Our results indicate that the intron 2 T/C polymorphism of CYP46 gene (neither alone, nor together with the ε4 allele) does not increase the susceptibility to late-onset sporadic AD in the Hungarian population.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalNeurochemical research
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 1 2005

    Fingerprint

Keywords

  • Alzheimer's disease
  • ApoE
  • CYP46
  • Gene polymorphism
  • Risk factor

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this