Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice

Viktoria Vereczki, Josef Mansour, Issa Pour-Ghaz, I. Bodnár, Otto Pinter, Dora Zelena, Erzsebet Oszwald, V. Ádám-Vizi, C. Chinopoulos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cyclophilin D (cypD) modulates the properties of the permeability transition pore, a phenomenon implicated in the manifestation of many diseases including aging. Here, we examined the effects of partial or complete deletion of cypD on i) lifespan, ii) forebrain protein expression of 18 aging markers as well as regional expression of GFAP, mGluR1, and alpha-synuclein, and iii) behaviour of aged (>. 24. month) male and female mice. Both male and female cypD heterozygous but not KO mice exhibited increased lifespans compared to WT littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour.

Original languageEnglish
JournalMitochondrion
DOIs
Publication statusAccepted/In press - Jun 13 2016

Keywords

  • Alpha-synuclein
  • GFAP
  • Heterozygote
  • MGluR1
  • Mitochondria
  • Permeability transition

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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