Cyclodextrin complexes of oleanolic and ursolic acid: Physico-chemical and biological preliminary evaluation

Cristina Trandafirescu, Diana Antal, Codruta Soica, Istvan Zupko, Renata Minorics, Rtia Ambrus, Florin Borcan, Camelia Oprean, Corina Danciu, Stefana Avram, Cristina Dehelean, Simona Nita, Lavinia Vlaia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Oleanolic and ursolic acids are two isomer triterpenic acids with a large number of various pharmacological activities. Their low water solubilities may explain their low bioavailability. Cyclodextrin complexation was used in order to increase the water solubility of the active substances. The resulted 1:1 complexes were physico-chemically analyzed using thermal analysis, X-ray diffraction and phase solubility studies. Preliminary in vitro investigations were conducted by means of MTTassay on three tumor cell lines: A431, A375 and BW 4A5. The entrapment of triterpenic acids inside the cyclodextrin cavity led to improved solubility as well as higher antiproliferative activity.

Original languageEnglish
Pages (from-to)1163-1167
Number of pages5
JournalRevista de Chimie
Volume65
Issue number10
Publication statusPublished - Oct 1 2014

    Fingerprint

Keywords

  • A375
  • A431
  • B16 4A5 cell line
  • DSC
  • MTT assay
  • Oleanolic
  • Phase solubility
  • Ursolic
  • X-ray

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Trandafirescu, C., Antal, D., Soica, C., Zupko, I., Minorics, R., Ambrus, R., Borcan, F., Oprean, C., Danciu, C., Avram, S., Dehelean, C., Nita, S., & Vlaia, L. (2014). Cyclodextrin complexes of oleanolic and ursolic acid: Physico-chemical and biological preliminary evaluation. Revista de Chimie, 65(10), 1163-1167.