Cyclocondensation of β-enaminonitriles, carbonyl compounds and acetonitrile. An effective route to various six-membered lactams

P. Nemes, B. Balazs, G. Toth, P. Scheiber

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Abstract

A cyclocondensation of β-enaminonitriles, carbonyl compounds and acetonitrile is described. Using different cyclic or open chain enaminonitriles various N-heterocycles were obtained in a one-step procedure. The base catalysed reaction was also carried out with α,β-unsaturated nitriles under similar conditions.

Original languageEnglish
Pages (from-to)1327-1329
Number of pages3
JournalSynlett
Issue number9
Publication statusPublished - Jan 1 2000

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Keywords

  • Alkaloid analogues
  • Cyclocondensation
  • Polycyclic lactams
  • α,β-Unsaturated nitriles
  • β-Enaminonitriles

ASJC Scopus subject areas

  • Organic Chemistry

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