Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids

H. Süli-Vargha, H. Medzihradszky-Schweiger, F. Ruff, K. Medzihrauszky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Intramolecular cyclization of the N - (2 - chloroethylcarbamoyl) derivatives of glycine, valine and phenylalanine give imidazolidone, oxazoline and hydantoin derivatives. The imidazolidone and oxazoline derivatives possess alkylating activity toward NBP. but the hydantoins do not. N - (2 - Chloroethylcarbamoyl)glycine reacts with the mercapto group of cysteine; thus, this alkylating group may be useful for receptor labelling.

Original languageEnglish
Pages (from-to)2255-2258
Number of pages4
JournalTetrahedron
Volume39
Issue number13
DOIs
Publication statusPublished - 1983

Fingerprint

Hydantoins
Cyclization
Glycine
Derivatives
Amino Acids
Valine
Phenylalanine
Cysteine
Labeling

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Süli-Vargha, H., Medzihradszky-Schweiger, H., Ruff, F., & Medzihrauszky, K. (1983). Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids. Tetrahedron, 39(13), 2255-2258. https://doi.org/10.1016/S0040-4020(01)91949-0

Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids. / Süli-Vargha, H.; Medzihradszky-Schweiger, H.; Ruff, F.; Medzihrauszky, K.

In: Tetrahedron, Vol. 39, No. 13, 1983, p. 2255-2258.

Research output: Contribution to journalArticle

Süli-Vargha, H, Medzihradszky-Schweiger, H, Ruff, F & Medzihrauszky, K 1983, 'Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids', Tetrahedron, vol. 39, no. 13, pp. 2255-2258. https://doi.org/10.1016/S0040-4020(01)91949-0
Süli-Vargha, H. ; Medzihradszky-Schweiger, H. ; Ruff, F. ; Medzihrauszky, K. / Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids. In: Tetrahedron. 1983 ; Vol. 39, No. 13. pp. 2255-2258.
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