Cyclic variation in myocardial gray level as a marker of viability in man

A videodensitometric study

C. Marini, E. Picano, A. Varga, P. Marzullo, A. Pingitore, M. Paterni

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Experimental and human studies have shown that a preserved cyclic (diastolic-to-systolic) echoreflectivity variation, assessed by radiofrequency sampling of backscatter signal with non-commercially available prototypes, identifies viability in a myocardial segment with a resting dyssynergy. The objective of this study was to assess whether a videodensitometric analysis of myocardial gray level variation during cardiac cycle might identify viable but dyssynergic myocardium in a clinical setting. Thirty-four patients with a resting dyssynergy (akinesis in 26, marked hypokinesis in eight) in the septum and/or infero-posterior wall were evaluated by videodensitometry. All echo studies were performed with commercially available instruments in the long axis parasternal view, with quantitative analysis of gray levels performed off-line on digitized images. Segmental wall motion was assessed with a 16 segment model of the left ventricle, each scored from 1, normal, to 4, dyskinetic. A follow-up echo study was obtained in all patients > 4 weeks after successful revascularization (in 22 by angioplasty, in 12 by bypass surgery). Two groups of segments were identified: 18 viable segments (contractile improvement of 1 grade or more in resting function after revascularization); 16 necrotic segments (no contractile improvement in resting function after revascularization). The % cyclic variation was higher in viable vs necrotic segments (26 ± 16 vs 1 ± 13%, P <0.01), in spite of similar % systolic thickening (5 ± 5 vs 4 ± 6%, P = ns) and end-diastolic thickness (10 ± 2 vs 10 ± 2 mm, P = ns). When individual patient analysis was performed, % cyclic variation was below the 95% confidence limits obtained from normal control regions (n = 34; % cyclic variation = 38 ± 14) in two out of 18 viable and in 14 out of 16 necrotic segments. A cut-off of ≥ 9.4% cyclic variations in a dyssynergic segment yielded 89% sensitivity and 88% specificity for predicting functional recovery following successful revascularization. In conclusion, viable dyssynergic myocardial segments show a cyclic gray level variation at rest, which can be detected by simple videodensitometric analysis, much less technologically demanding than radiofrequency backscatter evaluation.

Original languageEnglish
Pages (from-to)472-479
Number of pages8
JournalEuropean Heart Journal
Volume17
Issue number3
Publication statusPublished - 1996

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Angioplasty
Heart Ventricles
Myocardium
Sensitivity and Specificity

Keywords

  • Echocardiography
  • Necrosis
  • Tissue characterization
  • Viability
  • Videodensitometry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Marini, C., Picano, E., Varga, A., Marzullo, P., Pingitore, A., & Paterni, M. (1996). Cyclic variation in myocardial gray level as a marker of viability in man: A videodensitometric study. European Heart Journal, 17(3), 472-479.

Cyclic variation in myocardial gray level as a marker of viability in man : A videodensitometric study. / Marini, C.; Picano, E.; Varga, A.; Marzullo, P.; Pingitore, A.; Paterni, M.

In: European Heart Journal, Vol. 17, No. 3, 1996, p. 472-479.

Research output: Contribution to journalArticle

Marini, C, Picano, E, Varga, A, Marzullo, P, Pingitore, A & Paterni, M 1996, 'Cyclic variation in myocardial gray level as a marker of viability in man: A videodensitometric study', European Heart Journal, vol. 17, no. 3, pp. 472-479.
Marini, C. ; Picano, E. ; Varga, A. ; Marzullo, P. ; Pingitore, A. ; Paterni, M. / Cyclic variation in myocardial gray level as a marker of viability in man : A videodensitometric study. In: European Heart Journal. 1996 ; Vol. 17, No. 3. pp. 472-479.
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