Cyclic AMP does not affect the rate at which cells attach to a substratum

F. Grinnell, M. Milam, P. Srere

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

Cyclic AMP has been reported to increase the adhesion of fibroblasts to a substratum. In these experiments, theophylline and dibutyryl 3',5' adenosine monophosphate (dbcAMP) treated cells were shown to be less susceptible than nontreated cells to detachment from Falcon polystyrene tissue culture bottles. As cell detachment and cell attachment (the term 'stickiness' is used to mean the tendency to attach) are different properties of cell substratum interactions, the effects of theophylline and dbcAMP on cell 'stickiness' are measured. Although dbcAMP does decrease cell detachability, it does not increase the 'stickiness' of either transformed (BHK py) or normal (BHK 21-13s) baby hamster kidney cells.

Original languageEnglish
Title of host publicationNATURE NEW BIOL.
Pages82-83
Number of pages2
Volume241
Edition107
Publication statusPublished - 1973

Fingerprint

Cyclic AMP
Theophylline
Bucladesine
Polystyrenes
Cell Communication
Cricetinae
Fibroblasts
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Grinnell, F., Milam, M., & Srere, P. (1973). Cyclic AMP does not affect the rate at which cells attach to a substratum. In NATURE NEW BIOL. (107 ed., Vol. 241, pp. 82-83)

Cyclic AMP does not affect the rate at which cells attach to a substratum. / Grinnell, F.; Milam, M.; Srere, P.

NATURE NEW BIOL.. Vol. 241 107. ed. 1973. p. 82-83.

Research output: Chapter in Book/Report/Conference proceedingChapter

Grinnell, F, Milam, M & Srere, P 1973, Cyclic AMP does not affect the rate at which cells attach to a substratum. in NATURE NEW BIOL.. 107 edn, vol. 241, pp. 82-83.
Grinnell F, Milam M, Srere P. Cyclic AMP does not affect the rate at which cells attach to a substratum. In NATURE NEW BIOL.. 107 ed. Vol. 241. 1973. p. 82-83
Grinnell, F. ; Milam, M. ; Srere, P. / Cyclic AMP does not affect the rate at which cells attach to a substratum. NATURE NEW BIOL.. Vol. 241 107. ed. 1973. pp. 82-83
@inbook{cfb09d38d9f34704a919447e7759a2a0,
title = "Cyclic AMP does not affect the rate at which cells attach to a substratum",
abstract = "Cyclic AMP has been reported to increase the adhesion of fibroblasts to a substratum. In these experiments, theophylline and dibutyryl 3',5' adenosine monophosphate (dbcAMP) treated cells were shown to be less susceptible than nontreated cells to detachment from Falcon polystyrene tissue culture bottles. As cell detachment and cell attachment (the term 'stickiness' is used to mean the tendency to attach) are different properties of cell substratum interactions, the effects of theophylline and dbcAMP on cell 'stickiness' are measured. Although dbcAMP does decrease cell detachability, it does not increase the 'stickiness' of either transformed (BHK py) or normal (BHK 21-13s) baby hamster kidney cells.",
author = "F. Grinnell and M. Milam and P. Srere",
year = "1973",
language = "English",
volume = "241",
pages = "82--83",
booktitle = "NATURE NEW BIOL.",
edition = "107",

}

TY - CHAP

T1 - Cyclic AMP does not affect the rate at which cells attach to a substratum

AU - Grinnell, F.

AU - Milam, M.

AU - Srere, P.

PY - 1973

Y1 - 1973

N2 - Cyclic AMP has been reported to increase the adhesion of fibroblasts to a substratum. In these experiments, theophylline and dibutyryl 3',5' adenosine monophosphate (dbcAMP) treated cells were shown to be less susceptible than nontreated cells to detachment from Falcon polystyrene tissue culture bottles. As cell detachment and cell attachment (the term 'stickiness' is used to mean the tendency to attach) are different properties of cell substratum interactions, the effects of theophylline and dbcAMP on cell 'stickiness' are measured. Although dbcAMP does decrease cell detachability, it does not increase the 'stickiness' of either transformed (BHK py) or normal (BHK 21-13s) baby hamster kidney cells.

AB - Cyclic AMP has been reported to increase the adhesion of fibroblasts to a substratum. In these experiments, theophylline and dibutyryl 3',5' adenosine monophosphate (dbcAMP) treated cells were shown to be less susceptible than nontreated cells to detachment from Falcon polystyrene tissue culture bottles. As cell detachment and cell attachment (the term 'stickiness' is used to mean the tendency to attach) are different properties of cell substratum interactions, the effects of theophylline and dbcAMP on cell 'stickiness' are measured. Although dbcAMP does decrease cell detachability, it does not increase the 'stickiness' of either transformed (BHK py) or normal (BHK 21-13s) baby hamster kidney cells.

UR - http://www.scopus.com/inward/record.url?scp=0015813612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015813612&partnerID=8YFLogxK

M3 - Chapter

VL - 241

SP - 82

EP - 83

BT - NATURE NEW BIOL.

ER -