Cutting edge: Engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset

A. Barakonyi, Magali Rabot, Anne Marie-Cardine, Maryse Aguerre-Girr, B. Polgár, Vaĺerie Schiavon, Armand Bensussan, Philippe Le Bouteiller

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

CD160 is an Ig-like activating NK cell receptor expressed on the majority of circulating NK cells. This population corresponds to the nonproliferating, highly cytolytic, CD56dim CD16+ subset. CD160 engagement by HLA-C molecules mediates cytotoxic function. In this study, we report that upon specific activation by the physiological ligand HLA-C, or Ab cross-linking, CD160+ peripheral blood NK cells produce IFN-γ, TNF-α, and IL-6. This unique CD160-mediated cytokine production differs from the one observed after CD16 engagement whose expression is also restricted to the CD56dim cytotoxic NK cell subset. As already reported for the CD160-mediated cytotoxic effector function, CD160-mediated cytokine production by peripheral blood-NK cells is negatively controlled by the killer Ig-like receptor CD158b. Thus, the CD160 receptor represents a unique triggering surface molecule expressed by cytotoxic NK cells that participates in the inflammatory response and determines the type of subsequent specific immunity.

Original languageEnglish
Pages (from-to)5349-5354
Number of pages6
JournalJournal of Immunology
Volume173
Issue number9
Publication statusPublished - Nov 1 2004

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HLA-C Antigens
Natural Killer Cells
Blood Cells
Cytokines
Ligands
Natural Killer Cell Receptors
Immunity
Interleukin-6
Population

ASJC Scopus subject areas

  • Immunology

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Cutting edge : Engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset. / Barakonyi, A.; Rabot, Magali; Marie-Cardine, Anne; Aguerre-Girr, Maryse; Polgár, B.; Schiavon, Vaĺerie; Bensussan, Armand; Le Bouteiller, Philippe.

In: Journal of Immunology, Vol. 173, No. 9, 01.11.2004, p. 5349-5354.

Research output: Contribution to journalArticle

Barakonyi, A. ; Rabot, Magali ; Marie-Cardine, Anne ; Aguerre-Girr, Maryse ; Polgár, B. ; Schiavon, Vaĺerie ; Bensussan, Armand ; Le Bouteiller, Philippe. / Cutting edge : Engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset. In: Journal of Immunology. 2004 ; Vol. 173, No. 9. pp. 5349-5354.
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