Cutaneous vasculitis as an initiating paraneoplastic symptom in Hodgkin lymphoma

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Skin vasculitis may be associated with infections and autoimmune diseases. Furthermore, vasculitis may appear as a paraneoplastic symptom. A 19-year-old male patient was examined with swollen joints and papules presented on lower extremitis. Laboratory results showed high erythrocyte sedimentation ratio, positive C reactive protein, increased number of leukocytes and high circulating immune complex level. Histopatology of skin biopsy specimen proved vasculitis. ANCA was not present. No other changes could be observed besides skin involvement. Symptoms disappeared on 0.5-mg/bwkg methylprednisolon therapy. Few weeks later, enlarged cervical lymph nodes developed besides fever and weight loss. Biopsy indicated the presence of mixed cell type Hodgkin lymphoma. Appropriate examinations revealed clinical stage III/B with favorable prognosis (IPS = 2). After eight cycles of ABVD therapy complete remission was achieved as confirmed by FDG-PET. As a consequence of the treatment of Hodgkin lymphoma, vasculitis also disappeared. The present case report calls to attention the importance of careful examinations to exclude other diseases, especially malignancies that may remain at the background of cutaneous vasculitis. Treatment of the primary disease also results in the improvement of secondary skin vasculitis.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalRheumatology International
Volume28
Issue number7
DOIs
Publication statusPublished - May 2008

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Vasculitis
Hodgkin Disease
Skin
Biopsy
Antineutrophil Cytoplasmic Antibodies
Blood Sedimentation
Methylprednisolone
Therapeutics
Antigen-Antibody Complex
Leukocyte Count
C-Reactive Protein
Non-Hodgkin's Lymphoma
Autoimmune Diseases
Weight Loss
Fever
Joints
Lymph Nodes
Infection
Neoplasms

Keywords

  • Autoimmunity
  • Hodgkin lymphoma
  • Paraneoplastic syndrome
  • Therapy
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Cutaneous vasculitis as an initiating paraneoplastic symptom in Hodgkin lymphoma. / Simon, Zsófia; Tarr, T.; Tóth, L.; Szűcs, G.; Illés, A.

In: Rheumatology International, Vol. 28, No. 7, 05.2008, p. 719-723.

Research output: Contribution to journalArticle

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