Cutaneous lupus erythematosus: First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)

Cyrus Biazar, Johanna Sigges, Nikolaos Patsinakidis, Vincent Ruland, Susanne Amler, Gisela Bonsmann, Annegret Kuhn, M. Haust, F. Nyberg, Z. Bata-Csörgő, L. Mihályi, R. Olteanu, R. M. Pujol, J. M. Sánchez-Schmidt, L. Medenica, D. Skiljevic, A. Reich, J. C. Szepietowski, C. Dalle Vedove, G. GirolomoniT. Hawro, A. Zalewska-Janowska, R. Glaeser, R. Huegel, H. Jedlicková, A. Bygum, R. Laurinaviciene, S. Benoit, E. Broecker, F. A. Bahmer, E. Aberer, N. Wutte, J. Lipozencic, B. Marinovic, M. Sárdy, V. Bekou, T. Ruzicka, C. Frances, B. Soutou, H. Lee, M. Worm, A. Gruschke, N. Hunzelmann, K. Steinbrink, R. Romiti, M. Sticherling, C. Erfurt-Berge, G. Avgerinou, D. Papafragkaki, E. Antiga, M. Caproni, B. Mayer, B. Volc-Platzer, A. Kreuter, C. Tigges, P. M. Heil, G. Stingl

Research output: Contribution to journalArticle

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Abstract

In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years and differed significantly between the CLE subtypes. In 347 (34.6%) of the 1002 patients, two or more CLE subtypes were diagnosed during the course of the disease and 453 (45.2%) presented with LE-nonspecific manifestations. Drug-induced CLE and SjögrenD́s Syndrome had the highest prevalence in SCLE patients (13.1% and 14.0%, respectively). Photosensitivity was significantly more frequent in patients with ACLE, SCLE, and ICLE compared with those with CCLE. The detection of antinuclear antibodies such as anti-Ro/SSA and anti-La/SSB antibodies revealed further significant differences between the CLE subtypes. In summary, the EUSCLE Core Set Questionnaire and its database facilitate the analysis of clinical and laboratory features in a high number of patients with CLE and will contribute to standardized assessment and monitoring of the disease in Europe.

Original languageEnglish
Pages (from-to)444-454
Number of pages11
JournalAutoimmunity Reviews
Volume12
Issue number3
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Cutaneous Lupus Erythematosus
Databases
Age of Onset
Discoid Lupus Erythematosus
Antinuclear Antibodies
Systemic Lupus Erythematosus
Multicenter Studies

Keywords

  • Autoimmune disease
  • Cutaneous lupus erythematosus
  • Database analysis
  • Europe
  • Questionnaire

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Cutaneous lupus erythematosus : First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). / Biazar, Cyrus; Sigges, Johanna; Patsinakidis, Nikolaos; Ruland, Vincent; Amler, Susanne; Bonsmann, Gisela; Kuhn, Annegret; Haust, M.; Nyberg, F.; Bata-Csörgő, Z.; Mihályi, L.; Olteanu, R.; Pujol, R. M.; Sánchez-Schmidt, J. M.; Medenica, L.; Skiljevic, D.; Reich, A.; Szepietowski, J. C.; Dalle Vedove, C.; Girolomoni, G.; Hawro, T.; Zalewska-Janowska, A.; Glaeser, R.; Huegel, R.; Jedlicková, H.; Bygum, A.; Laurinaviciene, R.; Benoit, S.; Broecker, E.; Bahmer, F. A.; Aberer, E.; Wutte, N.; Lipozencic, J.; Marinovic, B.; Sárdy, M.; Bekou, V.; Ruzicka, T.; Frances, C.; Soutou, B.; Lee, H.; Worm, M.; Gruschke, A.; Hunzelmann, N.; Steinbrink, K.; Romiti, R.; Sticherling, M.; Erfurt-Berge, C.; Avgerinou, G.; Papafragkaki, D.; Antiga, E.; Caproni, M.; Mayer, B.; Volc-Platzer, B.; Kreuter, A.; Tigges, C.; Heil, P. M.; Stingl, G.

In: Autoimmunity Reviews, Vol. 12, No. 3, 01.2013, p. 444-454.

Research output: Contribution to journalArticle

Biazar, C, Sigges, J, Patsinakidis, N, Ruland, V, Amler, S, Bonsmann, G, Kuhn, A, Haust, M, Nyberg, F, Bata-Csörgő, Z, Mihályi, L, Olteanu, R, Pujol, RM, Sánchez-Schmidt, JM, Medenica, L, Skiljevic, D, Reich, A, Szepietowski, JC, Dalle Vedove, C, Girolomoni, G, Hawro, T, Zalewska-Janowska, A, Glaeser, R, Huegel, R, Jedlicková, H, Bygum, A, Laurinaviciene, R, Benoit, S, Broecker, E, Bahmer, FA, Aberer, E, Wutte, N, Lipozencic, J, Marinovic, B, Sárdy, M, Bekou, V, Ruzicka, T, Frances, C, Soutou, B, Lee, H, Worm, M, Gruschke, A, Hunzelmann, N, Steinbrink, K, Romiti, R, Sticherling, M, Erfurt-Berge, C, Avgerinou, G, Papafragkaki, D, Antiga, E, Caproni, M, Mayer, B, Volc-Platzer, B, Kreuter, A, Tigges, C, Heil, PM & Stingl, G 2013, 'Cutaneous lupus erythematosus: First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)', Autoimmunity Reviews, vol. 12, no. 3, pp. 444-454. https://doi.org/10.1016/j.autrev.2012.08.019
Biazar, Cyrus ; Sigges, Johanna ; Patsinakidis, Nikolaos ; Ruland, Vincent ; Amler, Susanne ; Bonsmann, Gisela ; Kuhn, Annegret ; Haust, M. ; Nyberg, F. ; Bata-Csörgő, Z. ; Mihályi, L. ; Olteanu, R. ; Pujol, R. M. ; Sánchez-Schmidt, J. M. ; Medenica, L. ; Skiljevic, D. ; Reich, A. ; Szepietowski, J. C. ; Dalle Vedove, C. ; Girolomoni, G. ; Hawro, T. ; Zalewska-Janowska, A. ; Glaeser, R. ; Huegel, R. ; Jedlicková, H. ; Bygum, A. ; Laurinaviciene, R. ; Benoit, S. ; Broecker, E. ; Bahmer, F. A. ; Aberer, E. ; Wutte, N. ; Lipozencic, J. ; Marinovic, B. ; Sárdy, M. ; Bekou, V. ; Ruzicka, T. ; Frances, C. ; Soutou, B. ; Lee, H. ; Worm, M. ; Gruschke, A. ; Hunzelmann, N. ; Steinbrink, K. ; Romiti, R. ; Sticherling, M. ; Erfurt-Berge, C. ; Avgerinou, G. ; Papafragkaki, D. ; Antiga, E. ; Caproni, M. ; Mayer, B. ; Volc-Platzer, B. ; Kreuter, A. ; Tigges, C. ; Heil, P. M. ; Stingl, G. / Cutaneous lupus erythematosus : First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). In: Autoimmunity Reviews. 2013 ; Vol. 12, No. 3. pp. 444-454.
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abstract = "In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years and differed significantly between the CLE subtypes. In 347 (34.6{\%}) of the 1002 patients, two or more CLE subtypes were diagnosed during the course of the disease and 453 (45.2{\%}) presented with LE-nonspecific manifestations. Drug-induced CLE and Sj{\"o}grenD́s Syndrome had the highest prevalence in SCLE patients (13.1{\%} and 14.0{\%}, respectively). Photosensitivity was significantly more frequent in patients with ACLE, SCLE, and ICLE compared with those with CCLE. The detection of antinuclear antibodies such as anti-Ro/SSA and anti-La/SSB antibodies revealed further significant differences between the CLE subtypes. In summary, the EUSCLE Core Set Questionnaire and its database facilitate the analysis of clinical and laboratory features in a high number of patients with CLE and will contribute to standardized assessment and monitoring of the disease in Europe.",
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T1 - Cutaneous lupus erythematosus

T2 - First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)

AU - Biazar, Cyrus

AU - Sigges, Johanna

AU - Patsinakidis, Nikolaos

AU - Ruland, Vincent

AU - Amler, Susanne

AU - Bonsmann, Gisela

AU - Kuhn, Annegret

AU - Haust, M.

AU - Nyberg, F.

AU - Bata-Csörgő, Z.

AU - Mihályi, L.

AU - Olteanu, R.

AU - Pujol, R. M.

AU - Sánchez-Schmidt, J. M.

AU - Medenica, L.

AU - Skiljevic, D.

AU - Reich, A.

AU - Szepietowski, J. C.

AU - Dalle Vedove, C.

AU - Girolomoni, G.

AU - Hawro, T.

AU - Zalewska-Janowska, A.

AU - Glaeser, R.

AU - Huegel, R.

AU - Jedlicková, H.

AU - Bygum, A.

AU - Laurinaviciene, R.

AU - Benoit, S.

AU - Broecker, E.

AU - Bahmer, F. A.

AU - Aberer, E.

AU - Wutte, N.

AU - Lipozencic, J.

AU - Marinovic, B.

AU - Sárdy, M.

AU - Bekou, V.

AU - Ruzicka, T.

AU - Frances, C.

AU - Soutou, B.

AU - Lee, H.

AU - Worm, M.

AU - Gruschke, A.

AU - Hunzelmann, N.

AU - Steinbrink, K.

AU - Romiti, R.

AU - Sticherling, M.

AU - Erfurt-Berge, C.

AU - Avgerinou, G.

AU - Papafragkaki, D.

AU - Antiga, E.

AU - Caproni, M.

AU - Mayer, B.

AU - Volc-Platzer, B.

AU - Kreuter, A.

AU - Tigges, C.

AU - Heil, P. M.

AU - Stingl, G.

PY - 2013/1

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AB - In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years and differed significantly between the CLE subtypes. In 347 (34.6%) of the 1002 patients, two or more CLE subtypes were diagnosed during the course of the disease and 453 (45.2%) presented with LE-nonspecific manifestations. Drug-induced CLE and SjögrenD́s Syndrome had the highest prevalence in SCLE patients (13.1% and 14.0%, respectively). Photosensitivity was significantly more frequent in patients with ACLE, SCLE, and ICLE compared with those with CCLE. The detection of antinuclear antibodies such as anti-Ro/SSA and anti-La/SSB antibodies revealed further significant differences between the CLE subtypes. In summary, the EUSCLE Core Set Questionnaire and its database facilitate the analysis of clinical and laboratory features in a high number of patients with CLE and will contribute to standardized assessment and monitoring of the disease in Europe.

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