Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe

Brian E. Mouthaan, Matea Rados, P. Barsi, Paul Boon, David W. Carmichael, Evelien Carrette, Dana Craiu, J. Helen Cross, Beate Diehl, Petia Dimova, Daniel Fabo, Stefano Francione, Vladislav Gaskin, Antonio Gil-Nagel, Elena Grigoreva, Alla Guekht, Edouard Hirsch, Hrvoje Hecimovic, Christoph Helmstaedter, Julien JungReetta Kalviainen, A. Kelemen, Vasilios Kimiskidis, Teia Kobulashvili, Pavel Krsek, Giorgi Kuchukhidze, Päl G. Larsson, Markus Leitinger, Morten I. Lossius, Roman Luzin, Kristina Malmgren, Ruta Mameniskiene, Petr Marusic, Baris Metin, Cigdem Özkara, Hrvoje Pecina, Carlos M. Quesada, Fergus Rugg-Gunn, Bertil Rydenhag, Philippe Ryvlin, Julia Scholly, Margitta Seeck, Anke M. Staack, Bernhard J. Steinhoff, Valentin Stepanov, Oana Tarta-Arsene, Eugen Trinka, Mustafa Uzan, Viola L. Vogt, Sjoerd B. Vos, Serge Vulliémoz, Geertjan Huiskamp, Frans S S Leijten, Pieter Van Eijsden, Kees P J Braun

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers. Methods A survey on the clinical use of imaging, electromagnetic source localization, and postprocessing methods in epilepsy surgery candidates was distributed among the 25 centers of the consortium. A descriptive analysis was performed, and results were compared to existing guidelines and recommendations. Results Response rate was 96%. Standard epilepsy magnetic resonance imaging (MRI) protocols are acquired at 3 Tesla by 15 centers and at 1.5 Tesla by 9 centers. Three centers perform 3T MRI only if indicated. Twenty-six different MRI sequences were reported. Six centers follow all guideline-recommended MRI sequences with the proposed slice orientation and slice thickness or voxel size. Additional sequences are used by 22 centers. MRI postprocessing methods are used in 16 centers. Interictal positron emission tomography (PET) is available in 22 centers; all using 18F-fluorodeoxyglucose (FDG). Seventeen centers perform PET postprocessing. Single-photon emission computed tomography (SPECT) is used by 19 centers, of which 15 perform postprocessing. Four centers perform neither PET nor SPECT in children. Seven centers apply magnetoencephalography (MEG) source localization, and nine apply electroencephalography (EEG) source localization. Fourteen combinations of inverse methods and volume conduction models are used. Significance We report a large variation in the presurgical diagnostic workup among epilepsy surgery centers across Europe. This diversity underscores the need for high-quality systematic reviews, evidence-based recommendations, and harmonization of available diagnostic presurgical methods.

Original languageEnglish
Pages (from-to)770-776
Number of pages7
JournalEpilepsia
Volume57
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Electromagnetic Phenomena
Epilepsy
Magnetic Resonance Imaging
Positron-Emission Tomography
Single-Photon Emission-Computed Tomography
Guidelines
Magnetoencephalography
Fluorodeoxyglucose F18
European Union
Neuroimaging
Electroencephalography

Keywords

  • Electromagnetic source imaging
  • Epilepsy surgery
  • Magnetic resonance imaging
  • Positron emission tomography
  • Single-photon emission computed tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Mouthaan, B. E., Rados, M., Barsi, P., Boon, P., Carmichael, D. W., Carrette, E., ... Braun, K. P. J. (2016). Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe. Epilepsia, 57(5), 770-776. https://doi.org/10.1111/epi.13347

Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe. / Mouthaan, Brian E.; Rados, Matea; Barsi, P.; Boon, Paul; Carmichael, David W.; Carrette, Evelien; Craiu, Dana; Cross, J. Helen; Diehl, Beate; Dimova, Petia; Fabo, Daniel; Francione, Stefano; Gaskin, Vladislav; Gil-Nagel, Antonio; Grigoreva, Elena; Guekht, Alla; Hirsch, Edouard; Hecimovic, Hrvoje; Helmstaedter, Christoph; Jung, Julien; Kalviainen, Reetta; Kelemen, A.; Kimiskidis, Vasilios; Kobulashvili, Teia; Krsek, Pavel; Kuchukhidze, Giorgi; Larsson, Päl G.; Leitinger, Markus; Lossius, Morten I.; Luzin, Roman; Malmgren, Kristina; Mameniskiene, Ruta; Marusic, Petr; Metin, Baris; Özkara, Cigdem; Pecina, Hrvoje; Quesada, Carlos M.; Rugg-Gunn, Fergus; Rydenhag, Bertil; Ryvlin, Philippe; Scholly, Julia; Seeck, Margitta; Staack, Anke M.; Steinhoff, Bernhard J.; Stepanov, Valentin; Tarta-Arsene, Oana; Trinka, Eugen; Uzan, Mustafa; Vogt, Viola L.; Vos, Sjoerd B.; Vulliémoz, Serge; Huiskamp, Geertjan; Leijten, Frans S S; Van Eijsden, Pieter; Braun, Kees P J.

In: Epilepsia, Vol. 57, No. 5, 01.05.2016, p. 770-776.

Research output: Contribution to journalArticle

Mouthaan, BE, Rados, M, Barsi, P, Boon, P, Carmichael, DW, Carrette, E, Craiu, D, Cross, JH, Diehl, B, Dimova, P, Fabo, D, Francione, S, Gaskin, V, Gil-Nagel, A, Grigoreva, E, Guekht, A, Hirsch, E, Hecimovic, H, Helmstaedter, C, Jung, J, Kalviainen, R, Kelemen, A, Kimiskidis, V, Kobulashvili, T, Krsek, P, Kuchukhidze, G, Larsson, PG, Leitinger, M, Lossius, MI, Luzin, R, Malmgren, K, Mameniskiene, R, Marusic, P, Metin, B, Özkara, C, Pecina, H, Quesada, CM, Rugg-Gunn, F, Rydenhag, B, Ryvlin, P, Scholly, J, Seeck, M, Staack, AM, Steinhoff, BJ, Stepanov, V, Tarta-Arsene, O, Trinka, E, Uzan, M, Vogt, VL, Vos, SB, Vulliémoz, S, Huiskamp, G, Leijten, FSS, Van Eijsden, P & Braun, KPJ 2016, 'Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe', Epilepsia, vol. 57, no. 5, pp. 770-776. https://doi.org/10.1111/epi.13347
Mouthaan, Brian E. ; Rados, Matea ; Barsi, P. ; Boon, Paul ; Carmichael, David W. ; Carrette, Evelien ; Craiu, Dana ; Cross, J. Helen ; Diehl, Beate ; Dimova, Petia ; Fabo, Daniel ; Francione, Stefano ; Gaskin, Vladislav ; Gil-Nagel, Antonio ; Grigoreva, Elena ; Guekht, Alla ; Hirsch, Edouard ; Hecimovic, Hrvoje ; Helmstaedter, Christoph ; Jung, Julien ; Kalviainen, Reetta ; Kelemen, A. ; Kimiskidis, Vasilios ; Kobulashvili, Teia ; Krsek, Pavel ; Kuchukhidze, Giorgi ; Larsson, Päl G. ; Leitinger, Markus ; Lossius, Morten I. ; Luzin, Roman ; Malmgren, Kristina ; Mameniskiene, Ruta ; Marusic, Petr ; Metin, Baris ; Özkara, Cigdem ; Pecina, Hrvoje ; Quesada, Carlos M. ; Rugg-Gunn, Fergus ; Rydenhag, Bertil ; Ryvlin, Philippe ; Scholly, Julia ; Seeck, Margitta ; Staack, Anke M. ; Steinhoff, Bernhard J. ; Stepanov, Valentin ; Tarta-Arsene, Oana ; Trinka, Eugen ; Uzan, Mustafa ; Vogt, Viola L. ; Vos, Sjoerd B. ; Vulliémoz, Serge ; Huiskamp, Geertjan ; Leijten, Frans S S ; Van Eijsden, Pieter ; Braun, Kees P J. / Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe. In: Epilepsia. 2016 ; Vol. 57, No. 5. pp. 770-776.
@article{017fa770fa564c2991362a9b9d2b5521,
title = "Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe",
abstract = "Objective In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers. Methods A survey on the clinical use of imaging, electromagnetic source localization, and postprocessing methods in epilepsy surgery candidates was distributed among the 25 centers of the consortium. A descriptive analysis was performed, and results were compared to existing guidelines and recommendations. Results Response rate was 96{\%}. Standard epilepsy magnetic resonance imaging (MRI) protocols are acquired at 3 Tesla by 15 centers and at 1.5 Tesla by 9 centers. Three centers perform 3T MRI only if indicated. Twenty-six different MRI sequences were reported. Six centers follow all guideline-recommended MRI sequences with the proposed slice orientation and slice thickness or voxel size. Additional sequences are used by 22 centers. MRI postprocessing methods are used in 16 centers. Interictal positron emission tomography (PET) is available in 22 centers; all using 18F-fluorodeoxyglucose (FDG). Seventeen centers perform PET postprocessing. Single-photon emission computed tomography (SPECT) is used by 19 centers, of which 15 perform postprocessing. Four centers perform neither PET nor SPECT in children. Seven centers apply magnetoencephalography (MEG) source localization, and nine apply electroencephalography (EEG) source localization. Fourteen combinations of inverse methods and volume conduction models are used. Significance We report a large variation in the presurgical diagnostic workup among epilepsy surgery centers across Europe. This diversity underscores the need for high-quality systematic reviews, evidence-based recommendations, and harmonization of available diagnostic presurgical methods.",
keywords = "Electromagnetic source imaging, Epilepsy surgery, Magnetic resonance imaging, Positron emission tomography, Single-photon emission computed tomography",
author = "Mouthaan, {Brian E.} and Matea Rados and P. Barsi and Paul Boon and Carmichael, {David W.} and Evelien Carrette and Dana Craiu and Cross, {J. Helen} and Beate Diehl and Petia Dimova and Daniel Fabo and Stefano Francione and Vladislav Gaskin and Antonio Gil-Nagel and Elena Grigoreva and Alla Guekht and Edouard Hirsch and Hrvoje Hecimovic and Christoph Helmstaedter and Julien Jung and Reetta Kalviainen and A. Kelemen and Vasilios Kimiskidis and Teia Kobulashvili and Pavel Krsek and Giorgi Kuchukhidze and Larsson, {P{\"a}l G.} and Markus Leitinger and Lossius, {Morten I.} and Roman Luzin and Kristina Malmgren and Ruta Mameniskiene and Petr Marusic and Baris Metin and Cigdem {\"O}zkara and Hrvoje Pecina and Quesada, {Carlos M.} and Fergus Rugg-Gunn and Bertil Rydenhag and Philippe Ryvlin and Julia Scholly and Margitta Seeck and Staack, {Anke M.} and Steinhoff, {Bernhard J.} and Valentin Stepanov and Oana Tarta-Arsene and Eugen Trinka and Mustafa Uzan and Vogt, {Viola L.} and Vos, {Sjoerd B.} and Serge Vulli{\'e}moz and Geertjan Huiskamp and Leijten, {Frans S S} and {Van Eijsden}, Pieter and Braun, {Kees P J}",
year = "2016",
month = "5",
day = "1",
doi = "10.1111/epi.13347",
language = "English",
volume = "57",
pages = "770--776",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe

AU - Mouthaan, Brian E.

AU - Rados, Matea

AU - Barsi, P.

AU - Boon, Paul

AU - Carmichael, David W.

AU - Carrette, Evelien

AU - Craiu, Dana

AU - Cross, J. Helen

AU - Diehl, Beate

AU - Dimova, Petia

AU - Fabo, Daniel

AU - Francione, Stefano

AU - Gaskin, Vladislav

AU - Gil-Nagel, Antonio

AU - Grigoreva, Elena

AU - Guekht, Alla

AU - Hirsch, Edouard

AU - Hecimovic, Hrvoje

AU - Helmstaedter, Christoph

AU - Jung, Julien

AU - Kalviainen, Reetta

AU - Kelemen, A.

AU - Kimiskidis, Vasilios

AU - Kobulashvili, Teia

AU - Krsek, Pavel

AU - Kuchukhidze, Giorgi

AU - Larsson, Päl G.

AU - Leitinger, Markus

AU - Lossius, Morten I.

AU - Luzin, Roman

AU - Malmgren, Kristina

AU - Mameniskiene, Ruta

AU - Marusic, Petr

AU - Metin, Baris

AU - Özkara, Cigdem

AU - Pecina, Hrvoje

AU - Quesada, Carlos M.

AU - Rugg-Gunn, Fergus

AU - Rydenhag, Bertil

AU - Ryvlin, Philippe

AU - Scholly, Julia

AU - Seeck, Margitta

AU - Staack, Anke M.

AU - Steinhoff, Bernhard J.

AU - Stepanov, Valentin

AU - Tarta-Arsene, Oana

AU - Trinka, Eugen

AU - Uzan, Mustafa

AU - Vogt, Viola L.

AU - Vos, Sjoerd B.

AU - Vulliémoz, Serge

AU - Huiskamp, Geertjan

AU - Leijten, Frans S S

AU - Van Eijsden, Pieter

AU - Braun, Kees P J

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objective In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers. Methods A survey on the clinical use of imaging, electromagnetic source localization, and postprocessing methods in epilepsy surgery candidates was distributed among the 25 centers of the consortium. A descriptive analysis was performed, and results were compared to existing guidelines and recommendations. Results Response rate was 96%. Standard epilepsy magnetic resonance imaging (MRI) protocols are acquired at 3 Tesla by 15 centers and at 1.5 Tesla by 9 centers. Three centers perform 3T MRI only if indicated. Twenty-six different MRI sequences were reported. Six centers follow all guideline-recommended MRI sequences with the proposed slice orientation and slice thickness or voxel size. Additional sequences are used by 22 centers. MRI postprocessing methods are used in 16 centers. Interictal positron emission tomography (PET) is available in 22 centers; all using 18F-fluorodeoxyglucose (FDG). Seventeen centers perform PET postprocessing. Single-photon emission computed tomography (SPECT) is used by 19 centers, of which 15 perform postprocessing. Four centers perform neither PET nor SPECT in children. Seven centers apply magnetoencephalography (MEG) source localization, and nine apply electroencephalography (EEG) source localization. Fourteen combinations of inverse methods and volume conduction models are used. Significance We report a large variation in the presurgical diagnostic workup among epilepsy surgery centers across Europe. This diversity underscores the need for high-quality systematic reviews, evidence-based recommendations, and harmonization of available diagnostic presurgical methods.

AB - Objective In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers. Methods A survey on the clinical use of imaging, electromagnetic source localization, and postprocessing methods in epilepsy surgery candidates was distributed among the 25 centers of the consortium. A descriptive analysis was performed, and results were compared to existing guidelines and recommendations. Results Response rate was 96%. Standard epilepsy magnetic resonance imaging (MRI) protocols are acquired at 3 Tesla by 15 centers and at 1.5 Tesla by 9 centers. Three centers perform 3T MRI only if indicated. Twenty-six different MRI sequences were reported. Six centers follow all guideline-recommended MRI sequences with the proposed slice orientation and slice thickness or voxel size. Additional sequences are used by 22 centers. MRI postprocessing methods are used in 16 centers. Interictal positron emission tomography (PET) is available in 22 centers; all using 18F-fluorodeoxyglucose (FDG). Seventeen centers perform PET postprocessing. Single-photon emission computed tomography (SPECT) is used by 19 centers, of which 15 perform postprocessing. Four centers perform neither PET nor SPECT in children. Seven centers apply magnetoencephalography (MEG) source localization, and nine apply electroencephalography (EEG) source localization. Fourteen combinations of inverse methods and volume conduction models are used. Significance We report a large variation in the presurgical diagnostic workup among epilepsy surgery centers across Europe. This diversity underscores the need for high-quality systematic reviews, evidence-based recommendations, and harmonization of available diagnostic presurgical methods.

KW - Electromagnetic source imaging

KW - Epilepsy surgery

KW - Magnetic resonance imaging

KW - Positron emission tomography

KW - Single-photon emission computed tomography

UR - http://www.scopus.com/inward/record.url?scp=84961574661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961574661&partnerID=8YFLogxK

U2 - 10.1111/epi.13347

DO - 10.1111/epi.13347

M3 - Article

C2 - 27012361

AN - SCOPUS:84961574661

VL - 57

SP - 770

EP - 776

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 5

ER -