Current trends and alternative scenarios in EBV research

J. Mináróvits, Hans Helmut Niller

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) infection is associated with several distinct hematological and epithelial malignancies, e.g., Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, gastric carcinoma, and others. The association with several malignant tumors of local and worldwide distribution makes EBV one of the most important tumor viruses. Furthermore, because EBV can cause posttransplant lymphoproliferative disease, transplant medicine has to deal with EBV as a major pathogenic virus second only to cytomegalovirus. In this review, we summarize briefly the natural history of EBV infection and outline some of the recent advances in the pathogenesis of the major EBV-associated neoplasms. We present alternative scenarios and discuss them in the light of most recent experimental data. Emerging research areas including EBV-induced patho-epigenetic alterations in host cells and the putative role of exosome-mediated information transfer in disease development are also within the scope of this review. This book contains an in-depth description of a series of modern methodologies used in EBV research. In this introductory chapter, we thoroughly refer to the applications of these methods and demonstrate how they contributed to the understanding of EBV-host cell interactions. The data gathered using recent technological advancements in molecular biology and immunology as well as the application of sophisticated in vitro and in vivo experimental models certainly provided deep and novel insights into the pathogenetic mechanisms of EBV infection and EBV-associated tumorigenesis. Furthermore, the development of adoptive T cell immunotherapy has provided a novel approach to the therapy of viral disease in transplant medicine and hematology.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-32
Number of pages32
Volume1532
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1532
ISSN (Print)10643745

Fingerprint

Human Herpesvirus 4
Research
Epstein-Barr Virus Infections
Medicine
Exosomes
Transplants
Oncogenic Viruses
Burkitt Lymphoma
Hematology
Virus Diseases
Hematologic Neoplasms
Allergy and Immunology
Cytomegalovirus
Hodgkin Disease
Epigenomics
Cell Communication
Immunotherapy
Molecular Biology
Neoplasms
Stomach

Keywords

  • Adoptive T cell immunotherapy
  • Burkitt lymphoma
  • EBV latency
  • Exosome
  • Hodgkin lymphoma
  • In vivo experimental models
  • Latent membrane protein 1 (LMP1)
  • Lytic viral replication
  • Mass spectrometry
  • Patho-epigenetics
  • RNA-seq
  • Telomere
  • Tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Mináróvits, J., & Niller, H. H. (2017). Current trends and alternative scenarios in EBV research. In Methods in Molecular Biology (Vol. 1532, pp. 1-32). (Methods in Molecular Biology; Vol. 1532). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6655-4_1

Current trends and alternative scenarios in EBV research. / Mináróvits, J.; Niller, Hans Helmut.

Methods in Molecular Biology. Vol. 1532 Humana Press Inc., 2017. p. 1-32 (Methods in Molecular Biology; Vol. 1532).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mináróvits, J & Niller, HH 2017, Current trends and alternative scenarios in EBV research. in Methods in Molecular Biology. vol. 1532, Methods in Molecular Biology, vol. 1532, Humana Press Inc., pp. 1-32. https://doi.org/10.1007/978-1-4939-6655-4_1
Mináróvits J, Niller HH. Current trends and alternative scenarios in EBV research. In Methods in Molecular Biology. Vol. 1532. Humana Press Inc. 2017. p. 1-32. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-6655-4_1
Mináróvits, J. ; Niller, Hans Helmut. / Current trends and alternative scenarios in EBV research. Methods in Molecular Biology. Vol. 1532 Humana Press Inc., 2017. pp. 1-32 (Methods in Molecular Biology).
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