Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy

Karen Sliwa, Denise Hilfiker-Kleiner, Mark C. Petrie, Alexandre Mebazaa, Burkert Pieske, Eckhart Buchmann, Vera Regitz-Zagrosek, Maria Schaufelberger, Luigi Tavazzi, Dirk J. Van Veldhuisen, Hugh Watkins, Ajay J. Shah, Petar M. Seferovic, Uri Elkayam, Sabine Pankuweit, Zoltan Papp, Frederic Mouquet, John J.V. McMurray

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Abstract

Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It typically develops during the last month of, and up to 6 months after, pregnancy in women without known cardiovascular disease. The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion is required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard, pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.

Original languageEnglish
Pages (from-to)767-778
Number of pages12
JournalEuropean journal of heart failure
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 1 2010

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Keywords

  • Definition
  • Peripartum cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sliwa, K., Hilfiker-Kleiner, D., Petrie, M. C., Mebazaa, A., Pieske, B., Buchmann, E., Regitz-Zagrosek, V., Schaufelberger, M., Tavazzi, L., Van Veldhuisen, D. J., Watkins, H., Shah, A. J., Seferovic, P. M., Elkayam, U., Pankuweit, S., Papp, Z., Mouquet, F., & McMurray, J. J. V. (2010). Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. European journal of heart failure, 12(8), 767-778. https://doi.org/10.1093/eurjhf/hfq120