Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy

A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy

Karen Sliwa, Denise Hilfiker-Kleiner, Mark C. Petrie, Alexandre Mebazaa, Burkert Pieske, Eckhart Buchmann, Vera Regitz-Zagrosek, Maria Schaufelberger, Luigi Tavazzi, Dirk J. Van Veldhuisen, Hugh Watkins, Ajay J. Shah, Petar M. Seferovic, Uri Elkayam, Sabine Pankuweit, Z. Papp, Frederic Mouquet, John J V McMurray

Research output: Contribution to journalArticle

452 Citations (Scopus)

Abstract

Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It typically develops during the last month of, and up to 6 months after, pregnancy in women without known cardiovascular disease. The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion is required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard, pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.

Original languageEnglish
Pages (from-to)767-778
Number of pages12
JournalEuropean Journal of Heart Failure
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Peripartum Period
Cardiomyopathies
Heart Failure
Prolactin
Therapeutics
Pregnancy
Ankle
Dyspnea
Oxidative Stress
Cardiovascular Diseases
Pharmacology
Morbidity
Mortality

Keywords

  • Definition
  • Peripartum cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy : A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. / Sliwa, Karen; Hilfiker-Kleiner, Denise; Petrie, Mark C.; Mebazaa, Alexandre; Pieske, Burkert; Buchmann, Eckhart; Regitz-Zagrosek, Vera; Schaufelberger, Maria; Tavazzi, Luigi; Van Veldhuisen, Dirk J.; Watkins, Hugh; Shah, Ajay J.; Seferovic, Petar M.; Elkayam, Uri; Pankuweit, Sabine; Papp, Z.; Mouquet, Frederic; McMurray, John J V.

In: European Journal of Heart Failure, Vol. 12, No. 8, 08.2010, p. 767-778.

Research output: Contribution to journalArticle

Sliwa, K, Hilfiker-Kleiner, D, Petrie, MC, Mebazaa, A, Pieske, B, Buchmann, E, Regitz-Zagrosek, V, Schaufelberger, M, Tavazzi, L, Van Veldhuisen, DJ, Watkins, H, Shah, AJ, Seferovic, PM, Elkayam, U, Pankuweit, S, Papp, Z, Mouquet, F & McMurray, JJV 2010, 'Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy', European Journal of Heart Failure, vol. 12, no. 8, pp. 767-778. https://doi.org/10.1093/eurjhf/hfq120
Sliwa, Karen ; Hilfiker-Kleiner, Denise ; Petrie, Mark C. ; Mebazaa, Alexandre ; Pieske, Burkert ; Buchmann, Eckhart ; Regitz-Zagrosek, Vera ; Schaufelberger, Maria ; Tavazzi, Luigi ; Van Veldhuisen, Dirk J. ; Watkins, Hugh ; Shah, Ajay J. ; Seferovic, Petar M. ; Elkayam, Uri ; Pankuweit, Sabine ; Papp, Z. ; Mouquet, Frederic ; McMurray, John J V. / Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy : A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. In: European Journal of Heart Failure. 2010 ; Vol. 12, No. 8. pp. 767-778.
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