Current state of ERG as biomarker in prostatic adenocarcinoma

Balazs Acs, Tibor Szarvas, Nora Szekely, Peter Nyirady, A. Marcell Szasz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this review we briefly discuss the possible biomarkers of prostate cancer among them we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas, we examine the incidence and detection of the most common genetic aberration in this tumor and its protein product as well. We also examined the correlation of clinicopathological factors and prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive markers.

Original languageEnglish
Pages (from-to)643-651
Number of pages9
JournalCurrent cancer drug targets
Volume15
Issue number8
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • Diagnosis
  • ERG
  • Prediction
  • Prognosis
  • Prostate carcinoma
  • TMPRSS2

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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