Current medical aspects of pantethine: Treatment strategies

Zoltan Horvath, L. Vécsei

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Coenzyme A is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, haem synthesis, acetylcholine synthesis, phase II detoxification, acetylation, etc. Pantethine has beneficial effects in vascular disease, it able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid-peroxidation. Moreover its neuro-endocrinological regulating role, its good influence on cataract and cystinosis are also proved. This molecule is a well-tolerated therapeutic agent; the frequency of its side-effect is very low and mild. Based on tbese preclinical and clinical data, it could be recommended using this compound as adjuvant therapy.

Original languageEnglish
Pages (from-to)220-229
Number of pages10
JournalIdeggyógyászati szemle
Volume62
Issue number7-8
Publication statusPublished - Jul 30 2009

Fingerprint

Carbohydrate Metabolism
Coenzyme A
Pantetheine
Phase II Metabolic Detoxication
Cystinosis
Acetylation
Hyperlipidemias
Pyruvic Acid
Heme
Vascular Diseases
Lipid Metabolism
Disulfides
Cataract
Lipid Peroxidation
Acetylcholine
Fatty Acids
Blood Platelets
Amino Acids
Therapeutics
pantethine

Keywords

  • Antioxidant
  • Atherosclerosis
  • Lipids
  • Pantethine
  • Platelets

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Current medical aspects of pantethine : Treatment strategies. / Horvath, Zoltan; Vécsei, L.

In: Ideggyógyászati szemle, Vol. 62, No. 7-8, 30.07.2009, p. 220-229.

Research output: Contribution to journalArticle

@article{f1f6eed37ebe434f9dfc4bef0b32e5c1,
title = "Current medical aspects of pantethine: Treatment strategies",
abstract = "Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Coenzyme A is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, haem synthesis, acetylcholine synthesis, phase II detoxification, acetylation, etc. Pantethine has beneficial effects in vascular disease, it able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid-peroxidation. Moreover its neuro-endocrinological regulating role, its good influence on cataract and cystinosis are also proved. This molecule is a well-tolerated therapeutic agent; the frequency of its side-effect is very low and mild. Based on tbese preclinical and clinical data, it could be recommended using this compound as adjuvant therapy.",
keywords = "Antioxidant, Atherosclerosis, Lipids, Pantethine, Platelets",
author = "Zoltan Horvath and L. V{\'e}csei",
year = "2009",
month = "7",
day = "30",
language = "English",
volume = "62",
pages = "220--229",
journal = "Ideggyogyaszati Szemle",
issn = "0019-1442",
publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",
number = "7-8",

}

TY - JOUR

T1 - Current medical aspects of pantethine

T2 - Treatment strategies

AU - Horvath, Zoltan

AU - Vécsei, L.

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Coenzyme A is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, haem synthesis, acetylcholine synthesis, phase II detoxification, acetylation, etc. Pantethine has beneficial effects in vascular disease, it able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid-peroxidation. Moreover its neuro-endocrinological regulating role, its good influence on cataract and cystinosis are also proved. This molecule is a well-tolerated therapeutic agent; the frequency of its side-effect is very low and mild. Based on tbese preclinical and clinical data, it could be recommended using this compound as adjuvant therapy.

AB - Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Coenzyme A is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, haem synthesis, acetylcholine synthesis, phase II detoxification, acetylation, etc. Pantethine has beneficial effects in vascular disease, it able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid-peroxidation. Moreover its neuro-endocrinological regulating role, its good influence on cataract and cystinosis are also proved. This molecule is a well-tolerated therapeutic agent; the frequency of its side-effect is very low and mild. Based on tbese preclinical and clinical data, it could be recommended using this compound as adjuvant therapy.

KW - Antioxidant

KW - Atherosclerosis

KW - Lipids

KW - Pantethine

KW - Platelets

UR - http://www.scopus.com/inward/record.url?scp=70349248026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349248026&partnerID=8YFLogxK

M3 - Article

C2 - 19685700

AN - SCOPUS:70349248026

VL - 62

SP - 220

EP - 229

JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

SN - 0019-1442

IS - 7-8

ER -