Current medical aspects of pantethine: Treatment strategies

Zoltan Horvath, Laszlo Vecsei

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Pantethine, the stable disulfide form of pantetheine, is the major precursor of coenzyme A, which plays a central role in the metabolism of lipids and carbohydrates. Coenzyme A is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, haem synthesis, acetylcholine synthesis, phase II detoxification, acetylation, etc. Pantethine has beneficial effects in vascular disease, it able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid-peroxidation. Moreover its neuro-endocrinological regulating role, its good influence on cataract and cystinosis are also proved. This molecule is a well-tolerated therapeutic agent; the frequency of its side-effect is very low and mild. Based on tbese preclinical and clinical data, it could be recommended using this compound as adjuvant therapy.

Original languageEnglish
Pages (from-to)220-229
Number of pages10
JournalIdeggyogyaszati szemle
Volume62
Issue number7-8
Publication statusPublished - Jul 30 2009

Keywords

  • Antioxidant
  • Atherosclerosis
  • Lipids
  • Pantethine
  • Platelets

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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