Current concepts in the genetic diagnostics of rheumatoid arthritis

Zsolt B. Nagy, Mónika Csanád, Katalin Tóth, Balzás Börzsönyi, Csaba Demendi, J. Rigó, József Gábor Joó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a systemic, chronic and inflammatory disease of unknown etiology. HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease. Currently, several immunopathogenetic models of other genes (CTLA4, MIF, PADI4 and SLC22A4) are under debate. The clinical influence of some of the gene polymorphisms associated with RA and the principles of pharmacogenetics applied to different therapies, such as classical disease-modifying anti-rheumatic drugs and new biological agents. Pharmacogenetics is a rapidly advancing area of research that holds the promise that therapies will soon be tailored to an individual patients genetic profile.

Original languageEnglish
Pages (from-to)603-618
Number of pages16
JournalExpert Review of Molecular Diagnostics
Volume10
Issue number5
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Genetic Phenomena
Rheumatoid Arthritis
Pharmacogenetics
Genes
HLA-DRB1 Chains
Antirheumatic Agents
Biological Factors
Autoimmune Diseases
Chronic Disease
Joints
Therapeutics
Research

Keywords

  • biological therapy
  • genetic diagnostics
  • pharmacogenetics
  • rheumatoid arthritis
  • single-nucleotide polymorphism

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Nagy, Z. B., Csanád, M., Tóth, K., Börzsönyi, B., Demendi, C., Rigó, J., & Joó, J. G. (2010). Current concepts in the genetic diagnostics of rheumatoid arthritis. Expert Review of Molecular Diagnostics, 10(5), 603-618. https://doi.org/10.1586/erm.10.36

Current concepts in the genetic diagnostics of rheumatoid arthritis. / Nagy, Zsolt B.; Csanád, Mónika; Tóth, Katalin; Börzsönyi, Balzás; Demendi, Csaba; Rigó, J.; Joó, József Gábor.

In: Expert Review of Molecular Diagnostics, Vol. 10, No. 5, 07.2010, p. 603-618.

Research output: Contribution to journalArticle

Nagy, ZB, Csanád, M, Tóth, K, Börzsönyi, B, Demendi, C, Rigó, J & Joó, JG 2010, 'Current concepts in the genetic diagnostics of rheumatoid arthritis', Expert Review of Molecular Diagnostics, vol. 10, no. 5, pp. 603-618. https://doi.org/10.1586/erm.10.36
Nagy, Zsolt B. ; Csanád, Mónika ; Tóth, Katalin ; Börzsönyi, Balzás ; Demendi, Csaba ; Rigó, J. ; Joó, József Gábor. / Current concepts in the genetic diagnostics of rheumatoid arthritis. In: Expert Review of Molecular Diagnostics. 2010 ; Vol. 10, No. 5. pp. 603-618.
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