Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors

Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "tool"?

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved. It is a multifactorial polygenic disease with probable genetic heterogeneity. Some genes are associated with IBD itself, while others increase the risk of ulcerative colitis (UC or Crohn's disease (CD) or are associated with disease location and/or behaviour. This review addresses recent advances in the genetics of IBD. The article discusses the current information on the crosstalk between microbial and genetic factors (e.g. NOD2/CARD15, SLC22A46A5 and DLG5). The genetic data acquired in recent years help in understanding the pathogenesis of IBD and can identify a number of potential targets for therapeutic intervention. In the future, genetics may help more accurately diagnose and predict disease course in IBD.

Original languageEnglish
Pages (from-to)1829-1841
Number of pages13
JournalWorld Journal of Gastroenterology
Volume12
Issue number12
Publication statusPublished - Mar 28 2006

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Microbial Genetics
Inflammatory Bowel Diseases
Bacteria
Genetic Heterogeneity
Ulcerative Colitis
Crohn Disease
Genes

Keywords

  • Crohn's disease
  • DLG5
  • Genetics
  • Inflammatory bowel disease
  • Microbial factors
  • NOD2/CARD15
  • Pathogenesis
  • SLC22A4/A5
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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abstract = "The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved. It is a multifactorial polygenic disease with probable genetic heterogeneity. Some genes are associated with IBD itself, while others increase the risk of ulcerative colitis (UC or Crohn's disease (CD) or are associated with disease location and/or behaviour. This review addresses recent advances in the genetics of IBD. The article discusses the current information on the crosstalk between microbial and genetic factors (e.g. NOD2/CARD15, SLC22A46A5 and DLG5). The genetic data acquired in recent years help in understanding the pathogenesis of IBD and can identify a number of potential targets for therapeutic intervention. In the future, genetics may help more accurately diagnose and predict disease course in IBD.",
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AU - Gal, Istvan

AU - Papp, J.

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