Korai stádiumú tüdõdaganatok kuratív sugárkezelése légzõmozgást figyelembe vevõ technikával

Translated title of the contribution: Curative radiotherapy of early-stage lung cancer using respiratory motion compensation

András Szilágyi, Tamás Pócza, C. Polgár, T. Major, András Bajcsay, József Lövey

Research output: Contribution to journalReview article

Abstract

In this paper we present our early experience with a method for the management of respiratory motion in radiotherapy for early-stage lung cancer. Forty-six patients were irradiated with a total dose of 60 Gy. Tumor response on control CT, survival, local and distant progression as well as early and late side effects were registered. Complete and partial remission, stable and progressive disease was 17 (37.0%), 15 (32.6%), 11 (23.9%) and 3 (6.5%). Isolated local recurrence and distant metastasis appeared in 4 (8.7%) and 2 (4.3%) cases, while simultaneous local and distant progression was diagnosed in 3 (6.5%) patients. The probability of 2-year local recurrence-free, progression-free, and overall survival was 76.8%, 64.0%, and 83.2%. Grade 1 (G1) and G2 early side effects occurred at 15 (32.6%) and 3 (6.5%) patients without ≥G3 side effects. G1 and G2 late side effects were observed in 10 (21.7%) and 7 (15.2%) cases. G1-2 post-irradiation fibrosis occurred in 11 (23.9%) cases. Twenty months after the irradiation, G5 respiration failure was developed in one patient. The implemented technique of respiratory motion management for the radiotherapy of early-stage lung cancer resulted in promising local freedom from relapse and survival with favorable side effect profile. Further follow-up is needed to assess longterm side effects and survival results.

Original languageHungarian
Pages (from-to)314-319
Number of pages6
JournalMagyar Onkologia
Volume60
Issue number4
Publication statusPublished - Nov 29 2016

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Lung Neoplasms
Radiotherapy
Recurrence
Survival
Disease-Free Survival
Respiration
Fibrosis
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Korai stádiumú tüdõdaganatok kuratív sugárkezelése légzõmozgást figyelembe vevõ technikával. / Szilágyi, András; Pócza, Tamás; Polgár, C.; Major, T.; Bajcsay, András; Lövey, József.

In: Magyar Onkologia, Vol. 60, No. 4, 29.11.2016, p. 314-319.

Research output: Contribution to journalReview article

Szilágyi, András ; Pócza, Tamás ; Polgár, C. ; Major, T. ; Bajcsay, András ; Lövey, József. / Korai stádiumú tüdõdaganatok kuratív sugárkezelése légzõmozgást figyelembe vevõ technikával. In: Magyar Onkologia. 2016 ; Vol. 60, No. 4. pp. 314-319.
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abstract = "In this paper we present our early experience with a method for the management of respiratory motion in radiotherapy for early-stage lung cancer. Forty-six patients were irradiated with a total dose of 60 Gy. Tumor response on control CT, survival, local and distant progression as well as early and late side effects were registered. Complete and partial remission, stable and progressive disease was 17 (37.0{\%}), 15 (32.6{\%}), 11 (23.9{\%}) and 3 (6.5{\%}). Isolated local recurrence and distant metastasis appeared in 4 (8.7{\%}) and 2 (4.3{\%}) cases, while simultaneous local and distant progression was diagnosed in 3 (6.5{\%}) patients. The probability of 2-year local recurrence-free, progression-free, and overall survival was 76.8{\%}, 64.0{\%}, and 83.2{\%}. Grade 1 (G1) and G2 early side effects occurred at 15 (32.6{\%}) and 3 (6.5{\%}) patients without ≥G3 side effects. G1 and G2 late side effects were observed in 10 (21.7{\%}) and 7 (15.2{\%}) cases. G1-2 post-irradiation fibrosis occurred in 11 (23.9{\%}) cases. Twenty months after the irradiation, G5 respiration failure was developed in one patient. The implemented technique of respiratory motion management for the radiotherapy of early-stage lung cancer resulted in promising local freedom from relapse and survival with favorable side effect profile. Further follow-up is needed to assess longterm side effects and survival results.",
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