CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury

Stefania Mondello, A. Büki, P. Barzó, Jeff Randall, Gail Provuncher, David Hanlon, David Wilson, Firas Kobeissy, Andreas Jeromin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The role of amyloid-β (Aβ) neuropathology and its significant changes in biofluids after traumatic brain injury (TBI) is still debated. We used ultrasensitive digital ELISA approach to assess amyloid-β1-42 (Aβ42) concentrations and time-course in cerebrospinal fluid (CSF) and in plasma of patients with severe TBI and investigated their relationship to injury characteristics, neurological status and clinical outcome. We found decreased CSF Aβ42 levels in TBI patients acutely after injury with lower levels in patients who died 6 months post-injury than in survivors. Conversely, plasma Aβ42 levels were significantly increased in TBI with lower levels in patients who survived. A trend analysis showed that both CSF and plasma Aβ42 levels strongly correlated with mortality. A positive correlation between changes in CSF Aβ42 concentrations and neurological status as assessed by Glasgow Coma Scale (GCS) was identified. Our results suggest that determination of Aβ42 may be valuable to obtain prognostic information in patients with severe TBI as well as in monitoring the response of the brain to injury.

Original languageEnglish
Article number06446
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - Oct 10 2014

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Amyloid
Cerebrospinal Fluid
Mortality
Wounds and Injuries
Glasgow Coma Scale
Traumatic Brain Injury
Brain Injuries
Survivors
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury. / Mondello, Stefania; Büki, A.; Barzó, P.; Randall, Jeff; Provuncher, Gail; Hanlon, David; Wilson, David; Kobeissy, Firas; Jeromin, Andreas.

In: Scientific Reports, Vol. 3, 06446, 10.10.2014.

Research output: Contribution to journalArticle

Mondello, Stefania ; Büki, A. ; Barzó, P. ; Randall, Jeff ; Provuncher, Gail ; Hanlon, David ; Wilson, David ; Kobeissy, Firas ; Jeromin, Andreas. / CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury. In: Scientific Reports. 2014 ; Vol. 3.
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