Crystallization and Resolution of cis-Permethric Acid with Carbon Dioxide Antisolvent

György Bánsághi, László Lorincz, Imre Miklós Szilágyi, János Madarász, Edit Székely

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Abstract

Crystallization and resolution of cis-permethric acid (cPA) with (1R)-1-phenylethanamine (PhEA) as a resolving agent was investigated by means of gas antisolvent (GAS) and supercritical antisolvent (SAS) methods. A significant pressure effect on both the yields and diastereomeric excesses of the crystallized cPA-PhEA salts was observed in a defined pressure range. The pressure effect was found to be related to the structure and dissociation of the salts. Both methods yielded diastereomeric salts with excellent diastereoselectivity, compared to data reported in literature, and a fibrous structure of uniform fiber diameter.

Original languageEnglish
Pages (from-to)1417-1421
Number of pages5
JournalChemical Engineering and Technology
Volume37
Issue number8
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Diastereomeric salt crystallization
  • Gas antisolvent process
  • Supercritical antisolvent process
  • Supercritical carbon dioxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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