Crystal structure of levomepromazine maleate

Gyula Tamás Gál, Nóra Veronika May, P. Bombicz

Research output: Contribution to journalArticle

Abstract

The asymmetric unit of the title salt, C19H25N2OS+ C4H3O4 - [systematic name: (S)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropanaminium hydrogen maleate], comprises two (S)-levomepromazine cations and two hydrogen maleate anions. The conformations of the two cations are similar. The major difference relates to the orientation of the methoxy substituent at the phenothiazine ring system. The crystal components form a three-dimensional supramolecular network via N - H⋯O, C - H⋯O and C - H⋯π interactions. A comparison of the conformations of the levomepromazine cations with those of the neutral molecule and similar protonated molecules reveals significant conformational flexibility of the phenothiazine ring system and the substituent at the phenothiazine N atom.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalActa Crystallographica Section E: Crystallographic Communications
Volume72
DOIs
Publication statusPublished - May 1 2016

Fingerprint

maleates
phenothiazines
Methotrimeprazine
Cations
Crystal structure
Positive ions
cations
crystal structure
Conformations
Hydrogen
Molecules
rings
hydrogen
Anions
molecules
flexibility
Negative ions
Salts
anions
salts

Keywords

  • C - H⋯π interactions
  • crystal structure
  • hydrogen bonding
  • maleate
  • phenothiazine

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Crystal structure of levomepromazine maleate. / Gál, Gyula Tamás; May, Nóra Veronika; Bombicz, P.

In: Acta Crystallographica Section E: Crystallographic Communications, Vol. 72, 01.05.2016, p. 612-615.

Research output: Contribution to journalArticle

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