Kryoglobulinamie und chronische Lebererkrankungen

Translated title of the contribution: Cryoglobulinemia in chronic liver diseases

A. Csepregi, E. Nemesánszky, M. Bély

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cryoglobulinemia can be associated with several infections, immunoproliferative tumors, chronic liver, renal and systemic autoimmune diseases. In the first part of the publication the authors give a review of the main clinical and laboratory properties of cryoglobulins. In essential mixed cryoglobulinemia syndrome (purpura, arthralgia, weakness) clinical and laboratory signs of damaged liver function can often be seen. However, there are mixed cryoglobulins in chronic liver disease of different etiologies as well. In 30-94% of patients with hepatitis C virus infection and hepatitis C virus-induced chronic liver diseases laboratory signs (occassionally clinical symptoms as well) of mixed cryoglobulinemia can be diagnosed. Serological markers of hepatitis C virus infection have been found in the cryoprecipitates of patients with mixed cryoglobulinemia. A high prevalence of mixed cryoglobulins in serum of patients with chronic hepatitis C virus infection and hepatitis C virus-induced chronic liver disease suggests that this virus has a significant role in the pathogenesis of mixed cryoglobulins. Also, an impaired clearance function of the liver in the uptake of cryo(immuno)complexes may be an important causative factor in the production of cryoglobulins in chronic liver diseases of different etiologies.

Original languageGerman
Pages (from-to)391-401
Number of pages11
JournalZeitschrift fur Gastroenterologie
Volume36
Issue number5
Publication statusPublished - 1998

Fingerprint

Cryoglobulins
Cryoglobulinemia
Hepacivirus
Liver Diseases
Chronic Disease
Virus Diseases
Liver
Purpura
Arthralgia
Chronic Hepatitis C
Autoimmune Diseases
Publications
Viruses
Kidney
Infection
Serum
Neoplasms

Keywords

  • Chronic liver diseases
  • Cryoglobulinemia
  • Hepatitis C virus
  • Interferon-α
  • Rheumatoid factor
  • Vasculitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kryoglobulinamie und chronische Lebererkrankungen. / Csepregi, A.; Nemesánszky, E.; Bély, M.

In: Zeitschrift fur Gastroenterologie, Vol. 36, No. 5, 1998, p. 391-401.

Research output: Contribution to journalArticle

Csepregi, A, Nemesánszky, E & Bély, M 1998, 'Kryoglobulinamie und chronische Lebererkrankungen', Zeitschrift fur Gastroenterologie, vol. 36, no. 5, pp. 391-401.
Csepregi, A. ; Nemesánszky, E. ; Bély, M. / Kryoglobulinamie und chronische Lebererkrankungen. In: Zeitschrift fur Gastroenterologie. 1998 ; Vol. 36, No. 5. pp. 391-401.
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