Crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling

P. Vilmos, Rui Sousa-Neves, Tamas Lukacsovich, J. Lawrence Marsh

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless (cv) gene of Drosophila encodes a new tsg-like gene. Genetic experiments show that cv, similarly to tsg, interacts with short gastrulation (sog) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These findings and the presence of two types of Tsg-like protein in several insects suggest that Cv represents a subgroup of the Tsg-like BMP-modulating proteins.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalEMBO Reports
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 2005

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Gastrulation
Bone Morphogenetic Proteins
Modulators
Genes
Insects
Proteins
Drosophila
Vertebrates
Ligands
Experiments

Keywords

  • BMP
  • Crossvein
  • Crossveinless
  • Drosophila melanogaster
  • Twisted gastrulation

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. / Vilmos, P.; Sousa-Neves, Rui; Lukacsovich, Tamas; Marsh, J. Lawrence.

In: EMBO Reports, Vol. 6, No. 3, 03.2005, p. 262-267.

Research output: Contribution to journalArticle

Vilmos, P. ; Sousa-Neves, Rui ; Lukacsovich, Tamas ; Marsh, J. Lawrence. / Crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. In: EMBO Reports. 2005 ; Vol. 6, No. 3. pp. 262-267.
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