Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

Carles Cantó, Anthony A. Sauve, P. Bai

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Poly(ADP-ribose) polymerases (PARPs) are NAD+ dependent enzymes that were identified as DNA repair proteins, however, today it seems clear that PARPs are responsible for a plethora of biological functions. Sirtuins (SIRTs) are NAD+-dependent deacetylase enzymes involved in the same biological processes as PARPs raising the question whether PARP and SIRT enzymes may interact with each other in physiological and pathophysiological conditions. Hereby we review the current understanding of the SIRT-PARP interplay in regard to the biochemical nature of the interaction (competition for the common NAD+ substrate, mutual posttranslational modifications and direct transcriptional effects) and the physiological or pathophysiological consequences of the interactions (metabolic events, oxidative stress response, genomic stability and aging). Finally, we give an overview of the possibilities of pharmacological intervention to modulate PARP and SIRT enzymes either directly, or through modulating NAD+ homeostasis.

Original languageEnglish
Pages (from-to)1168-1201
Number of pages34
JournalMolecular Aspects of Medicine
Volume34
Issue number6
DOIs
Publication statusPublished - Dec 2013

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Poly(ADP-ribose) Polymerases
Crosstalk
Sirtuins
NAD
Enzymes
Biological Phenomena
Oxidative stress
Genomic Instability
Post Translational Protein Processing
DNA Repair
Oxidative Stress
Homeostasis
Repair
Aging of materials
Pharmacology
DNA
Substrates
Proteins

Keywords

  • Metabolism
  • Mitochondria
  • NAD
  • Oxidative stress
  • Poly(ADP-ribose) polymerase
  • Sirtuins SIRT1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. / Cantó, Carles; Sauve, Anthony A.; Bai, P.

In: Molecular Aspects of Medicine, Vol. 34, No. 6, 12.2013, p. 1168-1201.

Research output: Contribution to journalArticle

Cantó, Carles ; Sauve, Anthony A. ; Bai, P. / Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. In: Molecular Aspects of Medicine. 2013 ; Vol. 34, No. 6. pp. 1168-1201.
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