Cross-section measurement of the 169Tm(p,n) reaction for the production of the therapeutic radionuclide 169Yb and comparison with its reactor-based generation

I. Spahn, S. Takács, Yu N. Shubin, F. Tárkányi, H. H. Coenen, S. M. Qaim

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22 Citations (Scopus)


The radionuclide 169Yb (T1/2=32.0d) is potentially important for internal radiotherapy. It is generally produced using a nuclear reactor. In this work the possibility of its production at a cyclotron was investigated. A detailed determination of the excitation function of the 169Tm(p,n) 169Yb reaction was done over the proton energy range up to 45 MeV using the stacked-foil technique and high-resolution γ-ray spectrometry. The integral yield of 169Yb was calculated. Over the optimum energy range EP=16→7MeV the yield amounts to 1.5 MBq/μA h and is thus rather low. A comparison of this production route with the established 168Yb(n,γ)169Yb reaction at a nuclear reactor is given. The 169Yb yield via the reactor route is by several orders of magnitude higher than by the cyclotron method. The latter procedure, however, leads to "no-carrier-added" product.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalApplied Radiation and Isotopes
Issue number2
Publication statusPublished - Aug 1 2005


  • Comparison of reactor and cyclotron production routes
  • Cross section
  • Integral yield
  • Nuclear reaction
  • Ytterbium-169

ASJC Scopus subject areas

  • Radiation

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