Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits

Z. Szilvássy, Matyas Koltai, P. Ferdinándy, Ildiko Jakab, J. Lonovics, Thierry Tarrade, Michel Allard, Pierre G. Braquet

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Myocardial ischemia assessed by intracavital ST-segment elevation, shortening of ventricular effective refractory period (VERP), and increase in left ventricular end-diastolic pressure (LVEDP) was provoked by ventricular overdrive pacing (VOP) in conscious rabbits. Cromakalim (10 μg/kg), an ATP-sensitive K+ channel opener, and cicletanine (30 mg/kg), a cGMP-phosphodiesterase inhibitor, reduced VOP-induced ST-segment elevation and LVEDP-increase. Under resting conditions, cromakalim lowered blood pressure, increased heart rate (HR), and shortened VERP, whereas cicletanine decreased HR, prolonged VERP without changing blood pressure. Co-administration of cromakalim and cicletanine additively reduced VOP-induced ST-segment elevation, shortening of VERP, and LVEDP-increase. Cicletanine did not change cromakalim-induced hypotension but abolished reflexogenic tachycardia. This suggests that VERP shortening is not a prerequisite for the anti-ischemic effect of cromakalim, and the combination of these drugs may afford a potent and safe anti-ischemic effect without affecting hypotension induced cromakalim.

Original languageEnglish
JournalLife Sciences
Volume54
Issue number9
DOIs
Publication statusPublished - 1994

Fingerprint

Cromakalim
Myocardial Ischemia
Refractory materials
Rabbits
Blood Pressure
Controlled Hypotension
Blood pressure
Heart Rate
Phosphodiesterase Inhibitors
Drug Combinations
Tachycardia
cicletanine
Adenosine Triphosphate

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits. / Szilvássy, Z.; Koltai, Matyas; Ferdinándy, P.; Jakab, Ildiko; Lonovics, J.; Tarrade, Thierry; Allard, Michel; Braquet, Pierre G.

In: Life Sciences, Vol. 54, No. 9, 1994.

Research output: Contribution to journalArticle

Szilvássy, Z. ; Koltai, Matyas ; Ferdinándy, P. ; Jakab, Ildiko ; Lonovics, J. ; Tarrade, Thierry ; Allard, Michel ; Braquet, Pierre G. / Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits. In: Life Sciences. 1994 ; Vol. 54, No. 9.
@article{f72806ffbf9648348241839d54dc028d,
title = "Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits",
abstract = "Myocardial ischemia assessed by intracavital ST-segment elevation, shortening of ventricular effective refractory period (VERP), and increase in left ventricular end-diastolic pressure (LVEDP) was provoked by ventricular overdrive pacing (VOP) in conscious rabbits. Cromakalim (10 μg/kg), an ATP-sensitive K+ channel opener, and cicletanine (30 mg/kg), a cGMP-phosphodiesterase inhibitor, reduced VOP-induced ST-segment elevation and LVEDP-increase. Under resting conditions, cromakalim lowered blood pressure, increased heart rate (HR), and shortened VERP, whereas cicletanine decreased HR, prolonged VERP without changing blood pressure. Co-administration of cromakalim and cicletanine additively reduced VOP-induced ST-segment elevation, shortening of VERP, and LVEDP-increase. Cicletanine did not change cromakalim-induced hypotension but abolished reflexogenic tachycardia. This suggests that VERP shortening is not a prerequisite for the anti-ischemic effect of cromakalim, and the combination of these drugs may afford a potent and safe anti-ischemic effect without affecting hypotension induced cromakalim.",
author = "Z. Szilv{\'a}ssy and Matyas Koltai and P. Ferdin{\'a}ndy and Ildiko Jakab and J. Lonovics and Thierry Tarrade and Michel Allard and Braquet, {Pierre G.}",
year = "1994",
doi = "10.1016/0024-3205(94)00870-1",
language = "English",
volume = "54",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits

AU - Szilvássy, Z.

AU - Koltai, Matyas

AU - Ferdinándy, P.

AU - Jakab, Ildiko

AU - Lonovics, J.

AU - Tarrade, Thierry

AU - Allard, Michel

AU - Braquet, Pierre G.

PY - 1994

Y1 - 1994

N2 - Myocardial ischemia assessed by intracavital ST-segment elevation, shortening of ventricular effective refractory period (VERP), and increase in left ventricular end-diastolic pressure (LVEDP) was provoked by ventricular overdrive pacing (VOP) in conscious rabbits. Cromakalim (10 μg/kg), an ATP-sensitive K+ channel opener, and cicletanine (30 mg/kg), a cGMP-phosphodiesterase inhibitor, reduced VOP-induced ST-segment elevation and LVEDP-increase. Under resting conditions, cromakalim lowered blood pressure, increased heart rate (HR), and shortened VERP, whereas cicletanine decreased HR, prolonged VERP without changing blood pressure. Co-administration of cromakalim and cicletanine additively reduced VOP-induced ST-segment elevation, shortening of VERP, and LVEDP-increase. Cicletanine did not change cromakalim-induced hypotension but abolished reflexogenic tachycardia. This suggests that VERP shortening is not a prerequisite for the anti-ischemic effect of cromakalim, and the combination of these drugs may afford a potent and safe anti-ischemic effect without affecting hypotension induced cromakalim.

AB - Myocardial ischemia assessed by intracavital ST-segment elevation, shortening of ventricular effective refractory period (VERP), and increase in left ventricular end-diastolic pressure (LVEDP) was provoked by ventricular overdrive pacing (VOP) in conscious rabbits. Cromakalim (10 μg/kg), an ATP-sensitive K+ channel opener, and cicletanine (30 mg/kg), a cGMP-phosphodiesterase inhibitor, reduced VOP-induced ST-segment elevation and LVEDP-increase. Under resting conditions, cromakalim lowered blood pressure, increased heart rate (HR), and shortened VERP, whereas cicletanine decreased HR, prolonged VERP without changing blood pressure. Co-administration of cromakalim and cicletanine additively reduced VOP-induced ST-segment elevation, shortening of VERP, and LVEDP-increase. Cicletanine did not change cromakalim-induced hypotension but abolished reflexogenic tachycardia. This suggests that VERP shortening is not a prerequisite for the anti-ischemic effect of cromakalim, and the combination of these drugs may afford a potent and safe anti-ischemic effect without affecting hypotension induced cromakalim.

UR - http://www.scopus.com/inward/record.url?scp=0028220928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028220928&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(94)00870-1

DO - 10.1016/0024-3205(94)00870-1

M3 - Article

C2 - 8114606

AN - SCOPUS:0028220928

VL - 54

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 9

ER -