Systemic autoimmune diseases characteristically show multiple organ involvements. Hence, Clinical manifestations and the outcome are quite variable. The survival has continuously been improving due to more sophisticated diagnostic tools and therapeutic possibilities. Despite the technical development, complications and organ manifestations may lead to emergency or often provoke permanent functional or morphologic deterioration of the affected organs. Critical situations can be directly attributed to the manifestations of the underlying disease, deterioration of the affected organs, side effects of immune suppressive therapy complications of Intercurrent or co-incidental diseases also may induce the occurrence of critical complications. The Authors describe all conditions that may lead to the development of critical situations at systemic autoimmune disease regarding different organ and organ systems. The symptoms and diagnostic possibilities are also analysed. A checklist is given about those systemic autoimmune disorders where particular critical events can be present. Medication in general and other possible immune modulator managements with beneficial effects are discussed.
|Translated title of the contribution||Critical situations in systemic autoimmune diseases|
|Number of pages||7|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Nov 1 2008|
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