Criteria for and Appropriateness of Renal Transplantation in Elderly Patients with End-Stage Renal Disease

A Literature Review and Position Statement on Behalf of the European Renal Association-European Dialysis and Transplant Association Descartes Working Group and European Renal Best Practice

Liviu Segall, Ionuţ Nistor, Julio Pascual, Istvan Mucsi, Lluis Guirado, Robert Higgins, Steven Van Laecke, Rainer Oberbauer, Wim Van Biesen, Daniel Abramowicz, Cristina Gavrilovici, Ken Farrington, Adrian Covic

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

During the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie ≥65 years of age) are still more rarely referred or accepted to waiting lists and, if enlisted, have less chances of actually receiving a kidney allograft, than younger counterparts. In this review, we looked at evidence for the benefits and risks of RT in the elderly trying to answer the following questions: Should RT be advocated for elderly patients? What should be the criteria to accept elderly patients on the waiting list for RT? What strategies might be used to increase the rate of RT in waitlisted elderly candidates? For selected elderly patients, RT was shown to be superior to dialysis in terms of patient survival. Virtually all guidelines recommend that patients should not be deemed ineligible for RT based on age alone, although a short life expectancy generally might preclude RT. Concerning the assessment of comorbidities in the elderly, special attention should be paid to cardiac evaluation and screening for malignancy. Comorbidity scores and frailty assessment scales might help the decision making on eligibility. Psychosocial issues should also be evaluated. To overcome the scarcity of organ donors, elderly RT candidates should be encouraged to consider expanded criteria donors and living donors, as alternatives to deceased standard criteria donors. It has been demonstrated that expanded criteria donor RT in patients 60 years or older is associated with higher survival rates than remaining on dialysis, whereas living donor RT is superior to all other options.

Original languageEnglish
Pages (from-to)e55-e65
JournalTransplantation
Volume100
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

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Practice Guidelines
Kidney Transplantation
Chronic Kidney Failure
Dialysis
Transplants
Kidney
Waiting Lists
Tissue Donors
Living Donors
Comorbidity
Life Expectancy
Allografts
Decision Making
Survival Rate
Guidelines
Survival

ASJC Scopus subject areas

  • Transplantation

Cite this

Criteria for and Appropriateness of Renal Transplantation in Elderly Patients with End-Stage Renal Disease : A Literature Review and Position Statement on Behalf of the European Renal Association-European Dialysis and Transplant Association Descartes Working Group and European Renal Best Practice. / Segall, Liviu; Nistor, Ionuţ; Pascual, Julio; Mucsi, Istvan; Guirado, Lluis; Higgins, Robert; Van Laecke, Steven; Oberbauer, Rainer; Van Biesen, Wim; Abramowicz, Daniel; Gavrilovici, Cristina; Farrington, Ken; Covic, Adrian.

In: Transplantation, Vol. 100, No. 10, 01.10.2016, p. e55-e65.

Research output: Contribution to journalReview article

Segall, Liviu ; Nistor, Ionuţ ; Pascual, Julio ; Mucsi, Istvan ; Guirado, Lluis ; Higgins, Robert ; Van Laecke, Steven ; Oberbauer, Rainer ; Van Biesen, Wim ; Abramowicz, Daniel ; Gavrilovici, Cristina ; Farrington, Ken ; Covic, Adrian. / Criteria for and Appropriateness of Renal Transplantation in Elderly Patients with End-Stage Renal Disease : A Literature Review and Position Statement on Behalf of the European Renal Association-European Dialysis and Transplant Association Descartes Working Group and European Renal Best Practice. In: Transplantation. 2016 ; Vol. 100, No. 10. pp. e55-e65.
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