CRF-containing neurons in the hypothalamic paraventricular nucleus: Regulation, especially by catecholamines

Éva Mezey, M. Palkóvits

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The neurons in the paraventricular nucleus that contain corticotropin-releasing factor (CRF) are regulated by humoral and neural inputs. Considerable evidence suggests that glucocorticoids act directly on these neurons to decrease their production of CRF. The paraventricular nuclei contain many peptides in addition to CRF and many different transmitters are found in afferent neurons that converge on them. These afferents include neurons from the subfornical organ that contain angiotensin II, neurons from the septum and elsewhere that contain enkephalin and substance P, neurons from the mesencephalon that contain serotonin, and neurons from the medulla oblongata that contain norepinephrine and epinephrine. The effects of catecholamines on CRF secretion remain controversial. Unilateral section of ascending norepinephrine-containing neurons leads to an ipsilateral decrease in paraventricular CRF content. However, there is appreciable evidence that epinephrine-containing neurons inhibit CRF secretion. A reasonable working hypothesis to explain the conflicting data is that there is a dual control: norepinephrine release from ascending neurons stimulates CRF secretion whereas epinephrine release inhibits CRF secretion.

Original languageEnglish
Pages (from-to)23-37
Number of pages15
JournalFrontiers in Neuroendocrinology
Volume12
Issue number1
Publication statusPublished - 1991

Fingerprint

Paraventricular Hypothalamic Nucleus
Corticotropin-Releasing Hormone
Catecholamines
Neurons
Epinephrine
Afferent Neurons
Norepinephrine
Subfornical Organ
Medulla Oblongata
Enkephalins
Substance P
Mesencephalon
Angiotensin II
Glucocorticoids
Serotonin
Peptides

Keywords

  • CRF
  • Epinephrine
  • Norepinephrine
  • Paraventricular nuclei

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

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title = "CRF-containing neurons in the hypothalamic paraventricular nucleus: Regulation, especially by catecholamines",
abstract = "The neurons in the paraventricular nucleus that contain corticotropin-releasing factor (CRF) are regulated by humoral and neural inputs. Considerable evidence suggests that glucocorticoids act directly on these neurons to decrease their production of CRF. The paraventricular nuclei contain many peptides in addition to CRF and many different transmitters are found in afferent neurons that converge on them. These afferents include neurons from the subfornical organ that contain angiotensin II, neurons from the septum and elsewhere that contain enkephalin and substance P, neurons from the mesencephalon that contain serotonin, and neurons from the medulla oblongata that contain norepinephrine and epinephrine. The effects of catecholamines on CRF secretion remain controversial. Unilateral section of ascending norepinephrine-containing neurons leads to an ipsilateral decrease in paraventricular CRF content. However, there is appreciable evidence that epinephrine-containing neurons inhibit CRF secretion. A reasonable working hypothesis to explain the conflicting data is that there is a dual control: norepinephrine release from ascending neurons stimulates CRF secretion whereas epinephrine release inhibits CRF secretion.",
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N2 - The neurons in the paraventricular nucleus that contain corticotropin-releasing factor (CRF) are regulated by humoral and neural inputs. Considerable evidence suggests that glucocorticoids act directly on these neurons to decrease their production of CRF. The paraventricular nuclei contain many peptides in addition to CRF and many different transmitters are found in afferent neurons that converge on them. These afferents include neurons from the subfornical organ that contain angiotensin II, neurons from the septum and elsewhere that contain enkephalin and substance P, neurons from the mesencephalon that contain serotonin, and neurons from the medulla oblongata that contain norepinephrine and epinephrine. The effects of catecholamines on CRF secretion remain controversial. Unilateral section of ascending norepinephrine-containing neurons leads to an ipsilateral decrease in paraventricular CRF content. However, there is appreciable evidence that epinephrine-containing neurons inhibit CRF secretion. A reasonable working hypothesis to explain the conflicting data is that there is a dual control: norepinephrine release from ascending neurons stimulates CRF secretion whereas epinephrine release inhibits CRF secretion.

AB - The neurons in the paraventricular nucleus that contain corticotropin-releasing factor (CRF) are regulated by humoral and neural inputs. Considerable evidence suggests that glucocorticoids act directly on these neurons to decrease their production of CRF. The paraventricular nuclei contain many peptides in addition to CRF and many different transmitters are found in afferent neurons that converge on them. These afferents include neurons from the subfornical organ that contain angiotensin II, neurons from the septum and elsewhere that contain enkephalin and substance P, neurons from the mesencephalon that contain serotonin, and neurons from the medulla oblongata that contain norepinephrine and epinephrine. The effects of catecholamines on CRF secretion remain controversial. Unilateral section of ascending norepinephrine-containing neurons leads to an ipsilateral decrease in paraventricular CRF content. However, there is appreciable evidence that epinephrine-containing neurons inhibit CRF secretion. A reasonable working hypothesis to explain the conflicting data is that there is a dual control: norepinephrine release from ascending neurons stimulates CRF secretion whereas epinephrine release inhibits CRF secretion.

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