Creatine phosphate suppresses ventricular arrhythmias resulting from coronary artery ligation

Olu Fagbemi, Kathleen A. Kane, J. Parratt

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effects of various doses of creatine phosphate have been examined in a rat model of acute myocardial ischaemia. When given directly into the lumen of the left ventricle in pentobarbitone-anaesthetised male rats, creatine phosphate (50 and 100 mg/kg) markedly reduced the incidence of ventricular ectopic beats, and especially the incidence and duration of the ventricular tachycardia and fibrillation which normally result from acute coronary artery ligation in this model. This protection was observed even if 1 or 2 h elapsed between creatine phosphate administration and coronary artery ligation. Electrophysiological studies on papillary muscles removed from rats 1 h after administration showed that creatine phosphate both decreased the maximum rate of depolarisation and prolonged the duration of the action potential. These results confirm our previous work in dogs that creatine phosphate is effective against early postinfarction ventricular arrhythmias, at least if given locally. It is suggested that these effects are due, at least in part, to a prolongation of the cardiac muscle action potential. Whether this is the result of maintaining energy production early in myocardial ischaemia is unclear.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume4
Issue number1
Publication statusPublished - 1982

Fingerprint

Phosphocreatine
Ligation
Cardiac Arrhythmias
Coronary Vessels
Action Potentials
Myocardial Ischemia
Ventricular Premature Complexes
Papillary Muscles
Incidence
Ventricular Fibrillation
Pentobarbital
Ventricular Tachycardia
Heart Ventricles
Myocardium
Dogs

Keywords

  • Coronary artery ligation
  • Creatine phosphate
  • Electrophysiology
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Creatine phosphate suppresses ventricular arrhythmias resulting from coronary artery ligation. / Fagbemi, Olu; Kane, Kathleen A.; Parratt, J.

In: Journal of Cardiovascular Pharmacology, Vol. 4, No. 1, 1982, p. 53-58.

Research output: Contribution to journalArticle

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