Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis - A case report

Adi Shahak, Emõke Pósán, Gabriella Szücs, János Rigó, Zoltan Boda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagulant therapy to coumarin, which induced skin necrosis. There appeared to be a possible causal relation between the severe immune reaction to heparin and the condition that predisposed to skin necrosis in the presence of coumarin. In patients who express a strong immune response to heparin, a different anticoagulant approach other than use of coumarin congeners appears to be justified.

Original languageEnglish
Pages (from-to)725-727
Number of pages3
JournalAngiology
Volume47
Issue number7
DOIs
Publication statusPublished - Jan 1 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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