Cost-of-illness studies in nine Central and Eastern European countries

Valentin Brodszky, Zsuzsanna Beretzky, Petra Baji, Fanni Rencz, Márta Péntek, Alexandru Rotar, Konstantin Tachkov, Susanne Mayer, Judit Simon, Maciej Niewada, Rok Hren, L. Gulácsi

Research output: Contribution to journalArticle


Background: To date, a multi-country review evaluating the cost-of-illness (COI) studies from the Central and Eastern European (CEE) region has not yet been published. Our main objective was to provide a general description about published COI studies from CEE. Methods: A systematic search was performed between 1 January 2006 and 1 June 2017 in Medline, EMBASE, The Cochrane Library, CINAHL, and Web of Science to identify all relevant COI studies from nine CEE countries. COI studies reporting costs without any restrictions by age, co-morbidities, or treatment were included. Methodology, publication standards, and cost results were analysed. Results: We identified 58 studies providing 83 country-specific COI results: Austria (n = 9), Bulgaria (n = 16), Croatia (n = 3), the Czech Republic (n = 10), Hungary (n = 24), Poland (n = 11), Romania (n = 3), Slovakia (n = 3), and Slovenia (n = 4). Endocrine, nutritional, and metabolic diseases (18%), neoplasms (12%), infections (11%), and neurological disorders (11%) were the most frequently studied clinical areas, and multiple sclerosis was the most commonly studied disease. Overall, 57 (98%) of the studies explicitly stated the source of resource use data, 45 (78%) the study perspective, 34 (64%) the costing method, and 24 (58%) reported at least one unit costs. Regardless of methodological differences, a positive relationship was observed between costs of diseases and countries’ per capita GDP. Conclusions: Cost-of-illness studies varied considerably in terms of methodology, publication practice, and clinical areas. Due to these heterogeneities, transferability of the COI results is limited across Central and Eastern European countries.

Original languageEnglish
Pages (from-to)155-172
Number of pages18
JournalEuropean Journal of Health Economics
Publication statusPublished - Jun 1 2019


  • Austria
  • Bulgaria
  • Central and Eastern Europe
  • Cost-of-illness
  • Croatia
  • Disease burden
  • Hungary
  • Poland
  • Romania
  • Slovakia
  • Slovenia
  • The Czech Republic

ASJC Scopus subject areas

  • Economics, Econometrics and Finance (miscellaneous)
  • Health Policy

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    Brodszky, V., Beretzky, Z., Baji, P., Rencz, F., Péntek, M., Rotar, A., Tachkov, K., Mayer, S., Simon, J., Niewada, M., Hren, R., & Gulácsi, L. (2019). Cost-of-illness studies in nine Central and Eastern European countries. European Journal of Health Economics, 20, 155-172.