Cost-of-illness of patients with systemic sclerosis in a tertiary care centre

Tünde Minier, Márta Péntek, Valentin Brodszky, Adrienn Ecseki, Krisztián Kárpáti, Anna Polgár, László Czirják, László Gulácsi

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37 Citations (Scopus)


Objective: The aim of our study was to assess the costs of SSc and to analyse cost drivers. Methods: A cross-sectional survey of consecutive patients with SSc was performed in a rheumatology centre in Hungary. Clinical characteristics, the European Scleroderma Study Group activity index, disease severity scale (DSS), scleroderma HAQ (S-HAQ) and health care utilization were recorded. Cost calculation was performed and correlation with clinical variables was analysed. Results were compared with RA and PsA. Results: Eighty patients were involved: 72 (90%) women, mean age (s.d.) 57.4 (9.6) years and disease duration of 6.2 (6.6) years and 25% of the cases had dcSSc. Mean total cost was 9619 (s.d. 6444) euros/patient/year with rate of indirect cost being 56%. Disability-related productivity loss (55.2%) and hospitalization (28.3%) were the highest among the cost items. Patients with dcSSc had significantly higher direct costs (P = 0.005) compared with the lcSSc subset. Disease activity showed significant correlation with total costs, DSS and S-HAQ with direct costs. SSc-related costs were higher than in matched RA and PsA cases. Conclusions: The cost-of-illness of SSc is high with a dominance of productivity loss related costs. Moreover, the disease activity is an important cost driver.

Original languageEnglish
Article numberkeq165
Pages (from-to)1920-1928
Number of pages9
Issue number10
Publication statusPublished - Jun 21 2010



  • Cost drivers
  • Costs-of-illness
  • Disability
  • Productivity loss
  • Scleroderma
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Minier, T., Péntek, M., Brodszky, V., Ecseki, A., Kárpáti, K., Polgár, A., Czirják, L., & Gulácsi, L. (2010). Cost-of-illness of patients with systemic sclerosis in a tertiary care centre. Rheumatology, 49(10), 1920-1928. [keq165].