Cortisol and alpha-2 adrenergic regulation of sympathoneural activity

K. Szemeredi, G. Bagdy, R. Stull, I. J. Kopin, D. S. Goldstein

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Alpha-2 adrenoceptor regulation of sympathoneural function was assessed in conscious, unrestrained Wistar-Kyoto rats during chronic glucocorticoid treatment. Cortisol administered for seven days via a subcutaneous reservoir pump increased blood pressure, decreased body weight and decreased plasma norepinephrine (NE) levels. In untreated animals, intravenous administration of the alpha-2 adrenoceptor antagonist, yohimbine, increased plasma levels of NE and of dihydroxyphenylglycol (DHPG), the main intraneuronal metabolite of NE. Cortisol treatment abolished these responses to yohimbine. Intravenous administration of clonidine, an agonist at alpha-2 adrenoceptors, decreased plasma NE levels; cortisol treatment did not affect the proportionate decreases in NE and DHPG levels produced by clonidine or alter the inhibitory effect of clonidine on reflexive catecholamine responses induced by sodium-nitroprusside. The results suggest that hypercortisolemia suppresses sympathetic activity and may also interfere indirectly with central neural noradrenergic mechanisms regulating sympathoneural outflow.

Original languageEnglish
Pages (from-to)445-454
Number of pages10
JournalBiogenic Amines
Volume7
Issue number5
Publication statusPublished - 1990

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Adrenergic Agents
Hydrocortisone
Norepinephrine
Clonidine
Adrenergic Receptors
Yohimbine
Intravenous Administration
Inbred WKY Rats
Nitroprusside
Glucocorticoids
Catecholamines
Therapeutics
Body Weight
Blood Pressure

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)

Cite this

Szemeredi, K., Bagdy, G., Stull, R., Kopin, I. J., & Goldstein, D. S. (1990). Cortisol and alpha-2 adrenergic regulation of sympathoneural activity. Biogenic Amines, 7(5), 445-454.

Cortisol and alpha-2 adrenergic regulation of sympathoneural activity. / Szemeredi, K.; Bagdy, G.; Stull, R.; Kopin, I. J.; Goldstein, D. S.

In: Biogenic Amines, Vol. 7, No. 5, 1990, p. 445-454.

Research output: Contribution to journalArticle

Szemeredi, K, Bagdy, G, Stull, R, Kopin, IJ & Goldstein, DS 1990, 'Cortisol and alpha-2 adrenergic regulation of sympathoneural activity', Biogenic Amines, vol. 7, no. 5, pp. 445-454.
Szemeredi K, Bagdy G, Stull R, Kopin IJ, Goldstein DS. Cortisol and alpha-2 adrenergic regulation of sympathoneural activity. Biogenic Amines. 1990;7(5):445-454.
Szemeredi, K. ; Bagdy, G. ; Stull, R. ; Kopin, I. J. ; Goldstein, D. S. / Cortisol and alpha-2 adrenergic regulation of sympathoneural activity. In: Biogenic Amines. 1990 ; Vol. 7, No. 5. pp. 445-454.
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