Corticotropin-releasing hormone expression in supraoptic neurons after bilateral lesioning of the paraventricular nucleus in rats

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Abstract

In situ hybridization histochemistry was used to demonstrate corticotropin releasing hormone (CRH) mRNA expression in the supraoptic nucleus of rats. Labeled cells with a range of grain densities were located mainly in the dorsal area of the nucleus. Long-term (6-weeks) lesioning of the hypothalamic paraventricular nucleus, which eliminates the major CRH pool from the hypothalamo-hypophyseal system resulted in an increased CRH mRNA density within supraoptic neurons compared to within sham-operated rats. Adrenalectomy failed to effect CRH mRNA content either in sham-operated or paraventricular-lesioned animals. CRH gene expression in supraoptic neurons of long-term paraventricular lesioned rats may exhibit a compensatory mechanism in the hypothalamus by which supraoptic neurons can take over some of the functions of the lesioned paraventricular CRH cells.

Original languageEnglish
Pages (from-to)423-430
Number of pages8
JournalNEUROBIOLOGY
Volume5
Issue number3
Publication statusPublished - Dec 1 1997

Keywords

  • Adrenalectomy
  • Corticotropin releasing hormone
  • In situ hybridization histochemistry
  • Paraventricular lesions
  • Supraoptic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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