Corticosterone binding in myocardial tissue of rats after chronic stress and adrenalectomy

A. Eller, C. Nyakas, G. Szabo, E. Endroczi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Male rats were trained to swim for 9-10 days to assess the effect of chronic stress on the capacity and affinity of specific glucocorticoid-binding in the cytosol fraction of myocardial tissue. A significant decrease in the binding capacity for corticosterone (Cpd B) was found 24 hours after the last swimming test, while the affinity constant remained unchanged. Contrary to Cpd-B binding, there was no change in the capacity of dexamethasone binding, and there was no decrease in the Cpd-B binding capacity in rats which had been adrenalectomized 2 days prior to the training period. We conclude that daily swimming for 9-10 days alters the number of cytoplasmic Cpd-B binding sites in the face of increased adrenocortical activity, while not affecting dexamethasone binding in the cytosol fraction of myocardial tissue.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume57
Issue number3
Publication statusPublished - 1981

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Adrenalectomy
Corticosterone
Cytosol
Dexamethasone
Glucocorticoids
Binding Sites

ASJC Scopus subject areas

  • Physiology

Cite this

Corticosterone binding in myocardial tissue of rats after chronic stress and adrenalectomy. / Eller, A.; Nyakas, C.; Szabo, G.; Endroczi, E.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 57, No. 3, 1981, p. 205-211.

Research output: Contribution to journalArticle

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