Corticosterone binding capacity increases in contralateral hippocampus after partial unilateral hippocampectomy

C. Nyakas, E. R. De Kloet, H. D. Veldhuis, B. Bohus

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

After unilateral dorsal hippocampectomy the binding of [3H]corticosterone to cytosol receptors in contralateral hippocampus was measured. For estimation of binding capacity the adrenals were removed bilaterally 24 h prior to sacrifice. The apparent maximal binding capacity (Bmax) for corticosterone in the contralateral hippocampus lobe was increased by 74 and 41%, respectively, 10 and 20 days after surgery. The data reveal a novel aspect of steroid receptor capacity control. It is suggested that compensation of altered amounts of receptor sites is an intrinsic property of the hippocampal corticosterone receptor system.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalNeuroscience Letters
Volume21
Issue number3
DOIs
Publication statusPublished - Feb 6 1981

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Corticosterone
Hippocampus
Steroid Receptors
Ambulatory Surgical Procedures
Cytosol
corticosterone receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Corticosterone binding capacity increases in contralateral hippocampus after partial unilateral hippocampectomy. / Nyakas, C.; De Kloet, E. R.; Veldhuis, H. D.; Bohus, B.

In: Neuroscience Letters, Vol. 21, No. 3, 06.02.1981, p. 339-343.

Research output: Contribution to journalArticle

Nyakas, C. ; De Kloet, E. R. ; Veldhuis, H. D. ; Bohus, B. / Corticosterone binding capacity increases in contralateral hippocampus after partial unilateral hippocampectomy. In: Neuroscience Letters. 1981 ; Vol. 21, No. 3. pp. 339-343.
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