Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

To investigate the involvement of different brain sites in the mediation of glucocorticoid feedback action, we implanted dexamethasone or corticosterone containing glass capillaries into the paraventricular and arcuate nuclei of the hypothalamus, into the lateral septum, the dorsal and ventral hippocampus, amygdala and the cerebral cortex of adrenalectomized male rats, and compared the plasma adrenocorticotropin (ACTH) values to those of the sham implanted controls. The ACTH hypersecretion of adrenalectomized (ADX), sham implanted rats (670 fmol/ml) was reduced significantly by dexamethasone implants placed into the paraventricular nucleus (9.97 fmol/ml), arcuate nucleus (20.54 fmol/ml) or lateral septum (44.15 fmol/ml). Corticosterone was effective only when placed into the dorsal hippocampus, but normal ACTH levels were not restored (219.67 fmol/ml). All other implants at other sites had no effect on ACTH secretion. Our results suggest that corticosterone and dexamethasone possess different feedback potencies and act at different sites in the brain to normalize the ADX-induced ACTH secretion.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalBrain Research
Volume474
Issue number2
DOIs
Publication statusPublished - Dec 6 1988

Fingerprint

Adrenalectomy
Corticosterone
Adrenocorticotropic Hormone
Dexamethasone
Brain
Arcuate Nucleus of Hypothalamus
Paraventricular Hypothalamic Nucleus
Hippocampus
Amygdala
Cerebral Cortex
Glucocorticoids
Glass

Keywords

  • Adrenocorticotropin
  • Feedback
  • Glucocorticoid
  • Hippocampus
  • Paraventricular nucleus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

@article{69c93c57b2874eb0bc7d6dde72387982,
title = "Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion",
abstract = "To investigate the involvement of different brain sites in the mediation of glucocorticoid feedback action, we implanted dexamethasone or corticosterone containing glass capillaries into the paraventricular and arcuate nuclei of the hypothalamus, into the lateral septum, the dorsal and ventral hippocampus, amygdala and the cerebral cortex of adrenalectomized male rats, and compared the plasma adrenocorticotropin (ACTH) values to those of the sham implanted controls. The ACTH hypersecretion of adrenalectomized (ADX), sham implanted rats (670 fmol/ml) was reduced significantly by dexamethasone implants placed into the paraventricular nucleus (9.97 fmol/ml), arcuate nucleus (20.54 fmol/ml) or lateral septum (44.15 fmol/ml). Corticosterone was effective only when placed into the dorsal hippocampus, but normal ACTH levels were not restored (219.67 fmol/ml). All other implants at other sites had no effect on ACTH secretion. Our results suggest that corticosterone and dexamethasone possess different feedback potencies and act at different sites in the brain to normalize the ADX-induced ACTH secretion.",
keywords = "Adrenocorticotropin, Feedback, Glucocorticoid, Hippocampus, Paraventricular nucleus",
author = "K. Kov{\'a}cs and G. Makara",
year = "1988",
month = "12",
day = "6",
doi = "10.1016/0006-8993(88)90435-0",
language = "English",
volume = "474",
pages = "205--210",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion

AU - Kovács, K.

AU - Makara, G.

PY - 1988/12/6

Y1 - 1988/12/6

N2 - To investigate the involvement of different brain sites in the mediation of glucocorticoid feedback action, we implanted dexamethasone or corticosterone containing glass capillaries into the paraventricular and arcuate nuclei of the hypothalamus, into the lateral septum, the dorsal and ventral hippocampus, amygdala and the cerebral cortex of adrenalectomized male rats, and compared the plasma adrenocorticotropin (ACTH) values to those of the sham implanted controls. The ACTH hypersecretion of adrenalectomized (ADX), sham implanted rats (670 fmol/ml) was reduced significantly by dexamethasone implants placed into the paraventricular nucleus (9.97 fmol/ml), arcuate nucleus (20.54 fmol/ml) or lateral septum (44.15 fmol/ml). Corticosterone was effective only when placed into the dorsal hippocampus, but normal ACTH levels were not restored (219.67 fmol/ml). All other implants at other sites had no effect on ACTH secretion. Our results suggest that corticosterone and dexamethasone possess different feedback potencies and act at different sites in the brain to normalize the ADX-induced ACTH secretion.

AB - To investigate the involvement of different brain sites in the mediation of glucocorticoid feedback action, we implanted dexamethasone or corticosterone containing glass capillaries into the paraventricular and arcuate nuclei of the hypothalamus, into the lateral septum, the dorsal and ventral hippocampus, amygdala and the cerebral cortex of adrenalectomized male rats, and compared the plasma adrenocorticotropin (ACTH) values to those of the sham implanted controls. The ACTH hypersecretion of adrenalectomized (ADX), sham implanted rats (670 fmol/ml) was reduced significantly by dexamethasone implants placed into the paraventricular nucleus (9.97 fmol/ml), arcuate nucleus (20.54 fmol/ml) or lateral septum (44.15 fmol/ml). Corticosterone was effective only when placed into the dorsal hippocampus, but normal ACTH levels were not restored (219.67 fmol/ml). All other implants at other sites had no effect on ACTH secretion. Our results suggest that corticosterone and dexamethasone possess different feedback potencies and act at different sites in the brain to normalize the ADX-induced ACTH secretion.

KW - Adrenocorticotropin

KW - Feedback

KW - Glucocorticoid

KW - Hippocampus

KW - Paraventricular nucleus

UR - http://www.scopus.com/inward/record.url?scp=0023798834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023798834&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(88)90435-0

DO - 10.1016/0006-8993(88)90435-0

M3 - Article

C2 - 2850089

AN - SCOPUS:0023798834

VL - 474

SP - 205

EP - 210

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -