Cortical projection of peripheral vestibular signaling

M. Emri, Mihály Kisely, Z. Lengyel, L. Balkay, T. Márián, László Mikó, Ervin Berényi, I. Sziklai, L. Trón, Ágnes Tóth

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The cerebral projection of vestibular signaling was studied by using PET with a special differential experimental protocol. Caloric vestibular stimulation (CVS)-induced regional cerebral blood flow (rCBF) changes were investigated in two populations. Butanol perfusion scans were carried out on six healthy volunteers and on six patients following the removal of tumors from the right cerebello pontine angle. The complete loss of the vestibular function postoperatively allowed a comparison of the rCBF changes in the populations with or without this input and offered a promising functional approach whereby to delineate the cortical region most responsive to pure vestibular input. The activations by left-sided and right-sided CVS were determined for both the healthy volunteers and the patient population. Statistical analysis of the data obtained following leftsided CVS did not reveal any cerebral region for which there was a significant difference in CVS-induced response by these two populations. In the case of right-sided CVS, however, the statistical comparison of the CVS-related responses demonstrated a single contralateral area characterized by a significantly different degree of response. This cortical area corresponds to part of the cortical region described recently which can be activated by both CVS and neck vibration. It appears to be anatomically identical to the aggregate of the somatosensory area SII and the retroinsular cortex described in primates, a region identified by other investigators as an analog of the parietoinsular vestibular cortex.

Original languageEnglish
Pages (from-to)2639-2646
Number of pages8
JournalJournal of Neurophysiology
Volume89
Issue number5
DOIs
Publication statusPublished - May 1 2003

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Cerebrovascular Circulation
Regional Blood Flow
Population
Healthy Volunteers
Butanols
Statistical Data Interpretation
Vibration
Primates
Neck
Perfusion
Research Personnel
Neoplasms

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Cortical projection of peripheral vestibular signaling. / Emri, M.; Kisely, Mihály; Lengyel, Z.; Balkay, L.; Márián, T.; Mikó, László; Berényi, Ervin; Sziklai, I.; Trón, L.; Tóth, Ágnes.

In: Journal of Neurophysiology, Vol. 89, No. 5, 01.05.2003, p. 2639-2646.

Research output: Contribution to journalArticle

Emri, M. ; Kisely, Mihály ; Lengyel, Z. ; Balkay, L. ; Márián, T. ; Mikó, László ; Berényi, Ervin ; Sziklai, I. ; Trón, L. ; Tóth, Ágnes. / Cortical projection of peripheral vestibular signaling. In: Journal of Neurophysiology. 2003 ; Vol. 89, No. 5. pp. 2639-2646.
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