Cortical and trabecular osteopenia after immobilization - A quantitative histological study of the rat knee

L. Józsa, A. Réffy, M. Järvinen, P. Kannus, M. Lehto, M. Kvist

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the knee was fixed in extension and in 18 in flexion. The time of immobilization was for 1, 2 and 3 weeks, with 12 animals in each group and 6 knees in extension and 6 in flexion. The following parameters were measured: (1) the mean thickness of subchondral and both periosteal cortices; (2) cortical porosity; (3) trabecular bone volume; (4) relative osteoid volume, and (5) relative osteoid surface. The mean cortical thickness decreased during the period of immobilization and the cortical porosity significantly increased. The trabecular bone volume was unaltered in the first week, but after 3 weeks it had decreased. The relative osteoid volume decreased significantly during the three weeks, and the relative osteoid surface moderately increased. No relationship was found between the quantitative osteopenic alteration of subchondral bone and the position of immobilization.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalInternational Orthopaedics
Volume12
Issue number2
DOIs
Publication statusPublished - Jul 1988

Fingerprint

Metabolic Bone Diseases
Immobilization
Knee
Porosity
Bone and Bones
Tibia
Cancellous Bone

Keywords

  • Immobilization
  • Osteopenia
  • Quantitative study
  • Rat knee

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Cortical and trabecular osteopenia after immobilization - A quantitative histological study of the rat knee. / Józsa, L.; Réffy, A.; Järvinen, M.; Kannus, P.; Lehto, M.; Kvist, M.

In: International Orthopaedics, Vol. 12, No. 2, 07.1988, p. 169-172.

Research output: Contribution to journalArticle

Józsa, L. ; Réffy, A. ; Järvinen, M. ; Kannus, P. ; Lehto, M. ; Kvist, M. / Cortical and trabecular osteopenia after immobilization - A quantitative histological study of the rat knee. In: International Orthopaedics. 1988 ; Vol. 12, No. 2. pp. 169-172.
@article{de42e8e019cf4265b2437e82d56049a2,
title = "Cortical and trabecular osteopenia after immobilization - A quantitative histological study of the rat knee",
abstract = "The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the knee was fixed in extension and in 18 in flexion. The time of immobilization was for 1, 2 and 3 weeks, with 12 animals in each group and 6 knees in extension and 6 in flexion. The following parameters were measured: (1) the mean thickness of subchondral and both periosteal cortices; (2) cortical porosity; (3) trabecular bone volume; (4) relative osteoid volume, and (5) relative osteoid surface. The mean cortical thickness decreased during the period of immobilization and the cortical porosity significantly increased. The trabecular bone volume was unaltered in the first week, but after 3 weeks it had decreased. The relative osteoid volume decreased significantly during the three weeks, and the relative osteoid surface moderately increased. No relationship was found between the quantitative osteopenic alteration of subchondral bone and the position of immobilization.",
keywords = "Immobilization, Osteopenia, Quantitative study, Rat knee",
author = "L. J{\'o}zsa and A. R{\'e}ffy and M. J{\"a}rvinen and P. Kannus and M. Lehto and M. Kvist",
year = "1988",
month = "7",
doi = "10.1007/BF00266984",
language = "English",
volume = "12",
pages = "169--172",
journal = "International Orthopaedics",
issn = "0341-2695",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Cortical and trabecular osteopenia after immobilization - A quantitative histological study of the rat knee

AU - Józsa, L.

AU - Réffy, A.

AU - Järvinen, M.

AU - Kannus, P.

AU - Lehto, M.

AU - Kvist, M.

PY - 1988/7

Y1 - 1988/7

N2 - The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the knee was fixed in extension and in 18 in flexion. The time of immobilization was for 1, 2 and 3 weeks, with 12 animals in each group and 6 knees in extension and 6 in flexion. The following parameters were measured: (1) the mean thickness of subchondral and both periosteal cortices; (2) cortical porosity; (3) trabecular bone volume; (4) relative osteoid volume, and (5) relative osteoid surface. The mean cortical thickness decreased during the period of immobilization and the cortical porosity significantly increased. The trabecular bone volume was unaltered in the first week, but after 3 weeks it had decreased. The relative osteoid volume decreased significantly during the three weeks, and the relative osteoid surface moderately increased. No relationship was found between the quantitative osteopenic alteration of subchondral bone and the position of immobilization.

AB - The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the knee was fixed in extension and in 18 in flexion. The time of immobilization was for 1, 2 and 3 weeks, with 12 animals in each group and 6 knees in extension and 6 in flexion. The following parameters were measured: (1) the mean thickness of subchondral and both periosteal cortices; (2) cortical porosity; (3) trabecular bone volume; (4) relative osteoid volume, and (5) relative osteoid surface. The mean cortical thickness decreased during the period of immobilization and the cortical porosity significantly increased. The trabecular bone volume was unaltered in the first week, but after 3 weeks it had decreased. The relative osteoid volume decreased significantly during the three weeks, and the relative osteoid surface moderately increased. No relationship was found between the quantitative osteopenic alteration of subchondral bone and the position of immobilization.

KW - Immobilization

KW - Osteopenia

KW - Quantitative study

KW - Rat knee

UR - http://www.scopus.com/inward/record.url?scp=0023779757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023779757&partnerID=8YFLogxK

U2 - 10.1007/BF00266984

DO - 10.1007/BF00266984

M3 - Article

C2 - 3045030

AN - SCOPUS:0023779757

VL - 12

SP - 169

EP - 172

JO - International Orthopaedics

JF - International Orthopaedics

SN - 0341-2695

IS - 2

ER -