Corrigendum to “Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities” [Steroids 105 (2016) 113–120](S0039128X15003013)(10.1016/j.steroids.2015.12.003)

G. Schneider, Anita Kiss, Erzsébet Mernyák, Zsanett Benke, János Wölfling, E. Frank, Noémi Bózsity, András Gyovai, Renáta Minorics, István Zupkó

Research output: Contribution to journalComment/debate

Abstract

The authors regret that an accidental interchange of the results concerning 19-nortestosterone (nandrolone, 1) and its epimer pair, 17α-19-nortestosterone (15) was made in Section 3.2 entitled “Determination of the antiproliferative properties of the 19-nortestosterone derivatives” and in the corresponding tables (Tables 1 and 2). As a consequence, in the related discussion, statements regarding compound 15 should now be interpreted as statements regarding compound 1. Nevertheless, it is to be noted that nandrolone (1) is a widely known androgenic anabolic steroid. Moreover, we would like to supplement our findings with the following: (a) the 17α-19-nortestosterone esters (15a–i) revealed better antiproliferative activities than that of their parent compound (15); (b) due to the steric positions of the functional groups at C17, these compounds are not able to interact with the androgen receptor. The design and synthesis of structural analogues of 15, therefore, still appear to be promising. The authors would like to apologize for any inconvenience caused.

Original languageEnglish
Pages (from-to)121
Number of pages1
JournalSteroids
Volume117
DOIs
Publication statusPublished - Jan 1 2017

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Endocrinology
  • Clinical Biochemistry
  • Organic Chemistry

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