Correspondence between structure and function of immunoglobulin G subclasses

V. P. Zav'yalov, V. M. Abramov, A. I. Ivannikov, O. I. Loseva, I. V. Dudich, E. I. Dudich, V. M. Tischenko, N. N. Khechinashvili, F. Franěk, G. Medgyesi, P. Závodszky, J. C. Jaton

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The studies revealed essential differences in the internal flexibility within and between domains and in the energy of non-covalent interactions between domains and subunits of immunoglobulins of different subclasses and of different animals. The higher extent of non-covalent interactions between the Fab and Fc subunits correlates with the lower extent of interactions between the CH2 and CH3 domains (the higher flexibility of the FC parts). Hapten-binding induces conformational changes in the Fc subunits of the immunoglobulins with strong non-covalent interactions between the Fab and Fc subunits.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalHaematologia
Volume14
Issue number1
Publication statusPublished - 1981

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Immunoglobulin Subunits
Immunoglobulin Fc Fragments
Haptens
Immunoglobulin G
Immunoglobulin Domains

ASJC Scopus subject areas

  • Hematology

Cite this

Zav'yalov, V. P., Abramov, V. M., Ivannikov, A. I., Loseva, O. I., Dudich, I. V., Dudich, E. I., ... Jaton, J. C. (1981). Correspondence between structure and function of immunoglobulin G subclasses. Haematologia, 14(1), 85-94.

Correspondence between structure and function of immunoglobulin G subclasses. / Zav'yalov, V. P.; Abramov, V. M.; Ivannikov, A. I.; Loseva, O. I.; Dudich, I. V.; Dudich, E. I.; Tischenko, V. M.; Khechinashvili, N. N.; Franěk, F.; Medgyesi, G.; Závodszky, P.; Jaton, J. C.

In: Haematologia, Vol. 14, No. 1, 1981, p. 85-94.

Research output: Contribution to journalArticle

Zav'yalov, VP, Abramov, VM, Ivannikov, AI, Loseva, OI, Dudich, IV, Dudich, EI, Tischenko, VM, Khechinashvili, NN, Franěk, F, Medgyesi, G, Závodszky, P & Jaton, JC 1981, 'Correspondence between structure and function of immunoglobulin G subclasses', Haematologia, vol. 14, no. 1, pp. 85-94.
Zav'yalov VP, Abramov VM, Ivannikov AI, Loseva OI, Dudich IV, Dudich EI et al. Correspondence between structure and function of immunoglobulin G subclasses. Haematologia. 1981;14(1):85-94.
Zav'yalov, V. P. ; Abramov, V. M. ; Ivannikov, A. I. ; Loseva, O. I. ; Dudich, I. V. ; Dudich, E. I. ; Tischenko, V. M. ; Khechinashvili, N. N. ; Franěk, F. ; Medgyesi, G. ; Závodszky, P. ; Jaton, J. C. / Correspondence between structure and function of immunoglobulin G subclasses. In: Haematologia. 1981 ; Vol. 14, No. 1. pp. 85-94.
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AU - Ivannikov, A. I.

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AU - Dudich, I. V.

AU - Dudich, E. I.

AU - Tischenko, V. M.

AU - Khechinashvili, N. N.

AU - Franěk, F.

AU - Medgyesi, G.

AU - Závodszky, P.

AU - Jaton, J. C.

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