In order to clarify the effects of methyl substitution on the carcinogenic activity, each resonance energy (RE) of benz[c]acridines, benzo[a]phenothiazines, chrysene, and their methyl derivatives was calculated by Aihara's TRE theory. Some correlations seem to exist between the values of resonance energy per π-electron for the cationic species, with the lack of the atom having the highest approximate superdelocalizability (Sr'((E))) from their parents skeleton, and carcinogenic activity.
|Number of pages||9|
|Issue number||5 A|
|Publication status||Published - Sep 1 1996|
- Effect of methyl substitution
- Resonance energy per π-electron
ASJC Scopus subject areas
- Cancer Research