Correlations between topological resonance energy of methyl-substituted benz[c]acridines, benzo[a]phenothiazines and chrysenes, and their carcinogenic or antitumor activities

Teruo Kurihara, Noboru Motohashi, Gui Lin Pang, Masaru Higano, Katsunori Kiguchi, Joseph Molnár

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18 Citations (Scopus)


In order to clarify the effects of methyl substitution on the carcinogenic activity, each resonance energy (RE) of benz[c]acridines, benzo[a]phenothiazines, chrysene, and their methyl derivatives was calculated by Aihara's TRE theory. Some correlations seem to exist between the values of resonance energy per π-electron for the cationic species, with the lack of the atom having the highest approximate superdelocalizability (Sr'((E))) from their parents skeleton, and carcinogenic activity.

Original languageEnglish
Pages (from-to)2757-2765
Number of pages9
JournalAnticancer research
Issue number5 A
Publication statusPublished - Sep 1 1996



  • Benz[c]acridine
  • Benzo[a]phenothiazine
  • Effect of methyl substitution
  • Resonance energy per π-electron

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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