Correlations between obesity and risk for salivary gland tumors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Visceral type obesity has close associations with insulin resistance and is regarded as high risk for both cardiovascular diseases and malignancies. Among obesity-associated tumors, cancers of the gastrointestinal tract, kidney, breast, pancreas, ovary and prostate were registered. Increased mass of visceral fat tissue has decreased insulin sensitivity and the reactive hyperinsulinemia provokes excessive lipolysis. High fatty acid levels in the portal circulation further increase the insulin resistance. As the elevated serum levels of glucose, insulin and IGFs have crucial role in cancer induction, visceral obesity means a high tumor risk. Correlations among visceral obesity and tumor risk are also strongly affected by the increased adipocytokine production of the mass of fatty tissue. These mediators thoroughly influence the insulin sensitivity and may have role in the inflammatory processes and tumor initiation. Obesity affects hormonal changes including increase in androgen, IGF and insulin levels and decrease of estrogen level. Recently, estrogen has been regarded as a potential mediator of the obesity induced breast cancer. However, a decreased obesity associated breast cancer risk was observed among postmenopausal cases treated by hormone replacement, which suggests that correlations between obesity and breast cancer are not mediated by estrogen. Obesity affects disadvantageously the tumor progression. Among obese patients with breast and colon cancers beneficial effects of physical activity and weight loss were observed, which decreased the risk of local recurrences and metastatic spread of tumors and improved life expectancies. In the present work a retrospective controlled study was performed to clarify the epidemiological associations between obesity, insulin resistance (elevated fasting glucose and type-2 diabetes) and salivary gland tumors. Salivary gland tumors had been surgically removed and histologically diagnosed (SGT group). Tumor free control patients underwent to dental surgeries were randomly selected (control group). Rates of cases with high body mass index (BMI), with elevated fasting glucose level and type-2 diabetes were established in the SGT and control groups. Obesity exhibited a significantly increased prevalence among pooled SGT cases as compared with the tumor-free controls (p<0.01). Separated investigation of the cases with malignant and benign SGT revealed that obesity was moderately higher risk for benign tumors both among male and female cases. Incidence of insulin resistant states was significantly higher in the pooled SGT group as compared with the tumor-free controls (p<0.01). Separated investigation of the male and female cases revealed that insulin resistance was higher risk factor for malignant SGTs in women as compared with men. In contrast, among the cases with benign SGT, insulin resistance rate was not significantly higher as compared with the controls either in women or in men. This work permits a novel hypothesis concerning a gender-related epidemiological correlation among obesity, insulin resistance and salivary gland tumors.

Original languageEnglish
Title of host publicationHorizons in Cancer Research. Volume 43
PublisherNova Science Publishers, Inc.
Pages45-58
Number of pages14
ISBN (Electronic)9781611224085
ISBN (Print)9781611220476
Publication statusPublished - Jan 1 2011

Fingerprint

Glandular and Epithelial Neoplasms
Obesity
Insulin Resistance
Neoplasms
Abdominal Obesity
Breast Neoplasms
Estrogens
Insulin
Glucose
Type 2 Diabetes Mellitus
Fasting
Control Groups
Adipokines
Gastrointestinal Neoplasms
Intra-Abdominal Fat
Lipolysis
Hyperinsulinism
Life Expectancy
Colonic Neoplasms
Androgens

Keywords

  • Elevated fasting glucose
  • Insulin resistance
  • Obesity
  • Salivary gland tumor
  • Type-2 diabetes

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Suba, Z. (2011). Correlations between obesity and risk for salivary gland tumors. In Horizons in Cancer Research. Volume 43 (pp. 45-58). Nova Science Publishers, Inc..

Correlations between obesity and risk for salivary gland tumors. / Suba, Z.

Horizons in Cancer Research. Volume 43. Nova Science Publishers, Inc., 2011. p. 45-58.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suba, Z 2011, Correlations between obesity and risk for salivary gland tumors. in Horizons in Cancer Research. Volume 43. Nova Science Publishers, Inc., pp. 45-58.
Suba Z. Correlations between obesity and risk for salivary gland tumors. In Horizons in Cancer Research. Volume 43. Nova Science Publishers, Inc. 2011. p. 45-58
Suba, Z. / Correlations between obesity and risk for salivary gland tumors. Horizons in Cancer Research. Volume 43. Nova Science Publishers, Inc., 2011. pp. 45-58
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