B-típusú natriureticus peptid és a nem geometriai echokardiográfi ás paraméterek összefüggé se gyermekkori szívizombetegségekben

Translated title of the contribution: Correlations between B-type natriuretic peptide levels and nongeometric echocardiographic parameters in pediatric cardiomyopathies

Kádár Krisztina, Bagoly Anna Zsuzsa, Sikos Zita

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Abstract

Introduction: B-type natriuretic peptide is a conventional cardiac biomarker in adult cardiology, however, it is not commonly used in pediatric cases. Aims: After introducing B-type natriuretic peptide measurements in pediatric patients for the evaluation of systemic right ventricular function, the authors wanted to evaluate the value of plasma B-type natriuretic peptide and compare the results with systolic and diastolic myocardial parameters obtained with conventional echocardiography and tissue Doppler imaging in children with cardiomyopathy. Methods: Between 2007 and 2010, 58 plasma B-type natriuretic peptide measurements were performed in 32 children (dilated cardiomyopathy in 20, hypertrophic cardiomyopathy in 10 and non-compacted cardiomyopathy in 2 cases). The age of the patients was 7.9±6.6 years (mean±SD). Plasma B-type natriuretic peptide was measured using an electrochemiluminescent assay within one day from echocardiographic evaluation. Results: As compared to normal values, children with the 3 types of cardiomyopathies showed signifi cant differences in plasma B-type natriutretic peptide levels ( dilated cardiomyopathy vs normal, p<0.001; hypertrophic cardiomyopathy vs. normal, p<0.01; non-compacted cardiomyopathy vs. normal, p<0.001). There was a signifi cant negative correlation (r = -0,63; p<0,01) between B-type natriuretic peptide levels (range, 12-7002 ng/L; mean±SD, 1531±1750 ng/L) and linEF values (range, 4-50%; mean±SD, 22.5±13%). For B-type natriuteric peptide, a cut-off point of 1000 ng/L proved to differentiate signifi cantly decreased linEF values (<17%). B-type natriuretic peptide levels signifi cantly correlated with left ventricular end-diastolic diameter (r = 0.899; p<0.001), with left ventricular anular S wave parameters (r = 0.689; p<0.001) and with E/e ratio (r = 0.43; p<0.05). Conclusions: B-type natriuretic peptide measurements are recommended in all types of cardiomyopathies.

Original languageHungarian
Pages (from-to)409-414
Number of pages6
JournalOrvosi hetilap
Volume154
Issue number11
DOIs
Publication statusPublished - Mar 1 2013

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ASJC Scopus subject areas

  • Medicine(all)

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