Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures

Dániel Veréb, Nikoletta Szabó, Bernadett Tuka, János Tajti, András Király, Péter Faragó, Krisztián Kocsis, Eszter Tóth, Bálint Kincses, Teréz Bagoly, Zsuzsanna Helyes, László Vécsei, Zsigmond Tamás Kincses

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4 Citations (Scopus)


OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.

Original languageEnglish
Pages (from-to)e1166-e1174
Issue number12
Publication statusPublished - Sep 18 2018

ASJC Scopus subject areas

  • Clinical Neurology

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    Veréb, D., Szabó, N., Tuka, B., Tajti, J., Király, A., Faragó, P., Kocsis, K., Tóth, E., Kincses, B., Bagoly, T., Helyes, Z., Vécsei, L., & Kincses, Z. T. (2018). Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures. Neurology, 91(12), e1166-e1174.